A compound having Formula III ** Formula ** and steroisomeric forms, mixtures of pharmaceutically acceptable salts, hydrates, solvates of such compounds, wherein: B is selected from C6-C10 aryl optionally substituted with one to 5 Y, C5-C10 cycloalkenyl optionally substituted with one to 7 Y, a 5- to 14-membered heteroaryl group optionally substituted with 1 to 8 Y, wherein said heteroaryl group comprises one, two or three heteroatoms selected from N, O, S； Y is from 1 to 5 substituents selected from the group consisting of hydrogen, halogen, -OCF3, -NO2, -CN, -CF3, a -C1-C6 alkyl, -C3-C6 cycloalkyl, -C2-C6 alkenyl, -alkynyl C2-C6, halo-C1-C6 alkyl, -alkyl (C0-C6) OR1, -alkyl (C0-C6) NR2R3, -alkyl (C0-C6) -C (>； = NR4) NR2R3, -alkyl (C0- C6) SR2, -alkyl (C0-C6) NR'C (>； = O) R3, -alkyl (C0-C6) NR2S (>； = O) 2R3, -alkyl (C0-C6) NR4C (>； = O) NR2R3 , -alkyl (C0-C6) -S (>； = O) R2, -alkyl (C0-C6) -S (>； = O) 2R2, -alkyl (C0-C6) -S (>； = O) 2NR2R3, - alkyl (C0-C6) C (>； = O) R2, -alkyl (C0-C6) C (>； = O) OR1, -alkyl (C0-C6) C (>； = O) NR2R3, -alkyl (C0-C6 ) C (>； = NR2) R3, or - (C0-C6) alkyl C (>； = NOR1) R3 optionally substituted, heteroaryl, heteroarylalkyl, arylalkyl, arylalkyl, alkylheteroaryl； wherein optionally two substituents combine with the intermediate atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring； wherein each ring is optionally further substituted with 1 to 5 halogen groups, -CN, -C1-C6 alkyl, -O-C0-C6 alkyl, -O-C3-C7 cycloalkyl, -O (aryl), -O (aryl ) -C0-C3 alkyl, -O (heteroaryl), -O (heteroaryl) -C0-C3 alkyl, -O (C1-C3) alkyl aryl, -O-(C1-C3) alkyl heteroaryl, -N (C0- alkyl C6) 2, -N (C0-C6 alkyl) alkyl (C0-C3) aryl or -N (C0-C6 alkyl) independent (C0-C3) heteroaryl alkyl； R1 at each occurrence is selected from hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -C3-C7 -cycloalkyl, 3- to 7-membered heterocycloalkyl, -C6-C10-aryl, 5- or 6-membered heteroaryl, C7- arylalkyl- C10, -C (>； = O) R5； R5 are selected from hydro
