CAMPBELL, STEWART,FOUDOULAKIS, HOPE,KIRK, BRIAN,RAM, SIYA,SESHADRI, HEMALATHA,BARTOLOZZI, ALESSANDRA,SWEETNAM, PAUL
申请号：
ES06748799
公开号：
ES2549397T3
申请日:
2006.03.27
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I: ** Formula ** or its pharmaceutically acceptable salts or hydrates, wherein: R1 is selected from the group consisting of -O- (CH2) and-CO2R12, -O- (CH2) and C (>； = O) NR13R14, -O- (CH2) and heteroaryl, -O- (CH2) and -cycloalkyl, -OC (>； = O) - (CH2) and-NR13R14, -O- (CH2) z-NR13R14, -NH- C (>； = O) - (CH2) and- NR13R14, -NH-C (>； = O) -X-R15, -NH- (CH2) and-NR13R14, and -NH- (CH2) -C (>； = O) -NR13R14； R12 is selected from the group consisting of C1-C6 alkyl, - (C1-C6 alkyl) -O- (C1-C6 alkyl), - (C1-C6 alkyl) - NR16R17, - (C1-C6 alkyl) -C ( >； = O) NR16R17, - (C1-C6 alkyl) -O- (C1-C6 alkyl) -O- (C1-C6 alkyl), aryl, aralkyl, heteroaryl, C3-C7 cycloalkyl, a heterocyclic ring from 3 to 12 members containing up to 3 heteroatoms, each of which may be optionally substituted on one or more carbon atoms with 1 to 3 substituents independently selected from halogen, C1-C6 alkoxy, hydroxy, amino, cyano and C1-C3 perfluoroalkyl； R13 and R14 are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, - (C1-C6 alkyl) -O- (C1-C6 alkyl), - (C1-alkyl C6) -NR16R17, - (C1-C6 alkyl) -C (>； = O) NR16R17, aryl, aralkyl, heteroaryl, C3-C7 cycloalkyl, a 3 to 12 membered heterocyclic ring containing up to 3 heteroatoms, each which may be optionally substituted with 1 to 3 substituents independently selected from halogen, C1-C6 alkyl, C2-C6 alkenyl, C3-C7 cycloalkyl, C1-C6 alkoxy, hydroxy, amino, cyano and C1-C3 perfluoroalkyl； or R13 and R14 can be considered together to form a 3 to 12 membered heterocyclic ring, having up to 3 heteroatoms, which is optionally substituted with 1 to 3 substituents independently selected from halogen, C1-C6 alkyl, C2-C6 alkenyl, alkoxy C1-C6, C3-C7 cycloalkyl, oxo, hydroxy, amino, cyano and C1-C3 perfluoroalkyl； X is selected from a covalent bond, O, NH, and C1-C6 alkyl； R15 is selected from the group consisting of H, aryl, heteroaryl, C3-C7 cycloalkyl, a 3 to 12 membered hetero
