HIPSKIND, PHILIP ARTHUR,TAKAKUWA, TAKAKO,JESUDASON, CYNTHIA DARSHINI,GADSKI, ROBERT ALAN,HORNBACK, WILLIAM JOSEPH,PICKARD, RICHARD TODD,BEAVERS, LISA SELSAM
申请号：
ES06758217
公开号：
ES2510490T3
申请日:
2006.03.28
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound structurally represented by Formula I ** Formula ** or a pharmaceutically acceptable salt thereof, for use in therapy, in which: X independently represents carbon or nitrogen, R1 is independently -halogen , -CN, -NO2, -C1-C7 alkyl (optionally substituted with 1 to 3 halogens), -C3-C8-cycloalkyl, -C1-C7 alkyl -S (O) 2-C1-alkyl C3), -C1-C7 alkyl -C (O) -O-R3, -C1-C7 alkyl -S (O) 2-phenyl (R2) (R2) (R2), -C1-alkyl C7) -S alkyl (C1-C7), -alkyl (C1-C7) -cycloalkyl (C3-C8), -alkyl (C1-C7) -phenyl (R2) (R2) (R2), -C (O) -phenyl (R2) (R2) (R2), -C (O) -C1-C7 alkyl, -C (O) -C3-C8 cycloalkyl, -C1-C7 alkyl-C (O) -phenyl (R2) (R2) (R2), -S-C1-C7 alkyl, -S-C1-C7 alkyl-phenyl (R2) (R2) (R2), -S-cycloalkyl (C3-) C8) - (C1-C7) alkyl, -S-cycloalkyl (C3-C8), -S-alkenyl (C2-C7), -Sphenyl (R2) (R2) (R2), -SO2-phenyl (R2) ( R2) (R2), -SO2R7, -S (O) R7, -alkyl (C2-C7), -cycloalkenyl (C3-C8), -alkenyl (C2-C7) -S (O) 2-alkyl (C1- C3), -alkenyl (C2 -C7) -C (O) -O-R3, -alkenyl (C2-C7) -S (O) 2-phenyl (R2) (R2) (R2), -alkenyl (C2-C7) -S15 alkyl (C1 -C7), -alkenyl (C2-C7) -cycloalkyl (C3-C8) or -alkenyl (C2-C7) -phenyl (R2) (R2) (R2)； R2 is, independently, at each occurrence -H, -halogen, -alkyl (C1-C7) (optionally substituted with 1 to 3 halogens), -C (O) R7, -C (O) OR7, -C ( O) cycloalkyl (C3-C8), -OCF3, -OR7, -SR7, -SO2R7, -SO2CF3 or -S (O) R7； R3 is, independently, at each occurrence -H or -C1-C3 alkyl (optionally substituted with 1 to 3 halogens)； R4 and R5 are, independently, at each occurrence -H, -halogen, -alkyl (C1-C3) (optionally substituted with 1 to 3 halogens) or -OR3, with the proviso that, when X is nitrogen, then R4 or R5 are not attached to X； R6 is, independently, at each occurrence -H, -halogen, -CF3, -alkyl (C1-C3) (optionally substituted with 1 to 3 halogens) or -OR3； and R7 is, independently, at each occurrence -H, -alkyl (C1-C2) (optionally substituted with 1 to 3 halogens) or -alkenyl (C2-C7).Un compuesto estructuralmente representado por la Fórmula I**Fórmu
