A compound of formula I or formula I ': ** Formula ** or a salt, hydrate, or ester thereof, in which: X is selected from a) -NR3-Y- b) -OY-, c) -S (O) mY-, d) -S (O) mNR3-Y-, e) -NR3S (O) mY-, f) -CC (O) R3-Y-, g) -C (S) NR3 -Y-, h) -NR3C (O) -Y-, i) NR3C (S) -Y-, j) -C (O) OY-, k) -OC (O) -Y- and l) a covalent bond ； And, at each occurrence, it is independently selected from a) a divalent C1-10 alkyl group, b) a divalent C2-10 alkenyl group, c) a divalent C2-10 alkynyl group, d) a divalent C1-10 haloalkyl group and ) a covalent bond； R1 is selected from a) a C1-10 alkyl group, b) a C3-14 cycloalkyl group, c) a 3-14 membered heterocycloalkyl group, d) a C8-14 polycyclic aryl group and e) a 5-14 heteroaryl group members, in which each group is optionally substituted with 1-4 -Y-R4； R2 is a C6-14 aryl group or a 5-14 membered heteroaryl group, in which each group is optionally substituted with 1-4 groups independently selected from -Y-R4 or -O-Y-R4； R3 is selected from a) H, b) a C1-10 alkyl group, c) a C2-10 alkenyl group, d) a C2-10 alkynyl group and e) a C1-10 haloalkyl group； R4, at each occurrence, is independently selected from a) halogen, b) -CN, c) -NO2, d) oxo, e) -OY-R5, f) -NR6-Y-R7, g) -N (O ) R6-Y-R7, h) -S (O) mY-R5, i) -S (O) mOYR5, j) -S (O) mNR6-Y-R7, k) -C (O) YR5, l ) -C (O) OY-R5, m) -C (O) NR6-Y-R7, n) -C (S) NR6-Y-R7, or) a C1-10 alkyl group, p) an alkenyl group C2-10, q) a C2-10 alkynyl group, r) a C1-10 haloalkyl group, s) a C3-14 cycloalkyl group, t) a C6-14 aryl group, u) a 3-14 membered cycloheteroalkyl group and v) a 5-14 membered heteroaryl group, in which each of o) - v) is optionally substituted with 1-4 -Y-R8 groups； R5, at each occurrence, is independently selected from a) H, b) -C (O) R9, c) -C (O) OR9, d) a C1-10 alkyl group, e) a C2-10 alkenyl group, f) a C2-10 alkynyl group, g) a C1-10 haloalkyl group, h) a C3-14 cycloalkyl group, i) a C6-14 aryl group, j) a 3-14 membered cycloheteroalkyl group and k) a group 5-14 heteroaryl member
