TONG, Yunsong,PENNING, Thomas,FLORJANCIC, Alan,MIYASHIRO, Julie,WOODS, Keith W.
申请号：
ES12716781
公开号：
ES2587514T3
申请日:
2012.02.27
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of the formula (I): ** Formula ** wherein X is N or CR1； Y is N or CR2； Z is O, S, or NH； R1 is H or C1-6-alkyl； R2 is H or C1-6-alkyl； R3 is C1-8-alkyl, C2-8-alkenyl, C3-8-cycloalkyl, aryl, or heteroaryl, wherein (a) C1-8-alkyl or C2-8-alkenyl is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, nitro, -ORa, -C (O) Ra, -C (O) ORa, -OC (O) R a, -NRbRc, -NRbC (O) Ra, -NHC (O ) NHRb, -C (O) NRbRc, -NHSO2Ra, and -SO2NRbNRc； and (b) C3-8-cycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of C1-6-alkyl, C1-6-haloalkyl, C2-6-alkenyl, heterocycloalkyl, aryl, heteroaryl, halogen, oxo, cyano, nitro, -ORd, -C (O) Rd, -C (O) ORd, -OC (O) Rd, -SRd, - S (O) Rd, -SO2Rd, -NReRf, -NHC (O) Re, -NHC (O) NHRe, -NHC (O) ORe, -NHSO2Rd, -C (O) NHRe, and -SO2NHNRe； R4 is (a) phenyl, naphthyl, tetrahydronaphthyl, indenyl, or indanyl, wherein phenyl, naphthyl, tetrahydronaphthyl, indenyl, or indanyl are optionally substituted with one or more R5； or (b) 5-16 membered monocyclic, bicyclic, or tricyclic heterocyclyl, wherein the heterocyclyl is optionally substituted with one or more R6； R5, at each occurrence, is independently CN, NO2, halo, C1-6-alkyl, ORg, SRg, C (O) Rg, C (O) NRhRi, C (O) ORg, NRhRi, NRhC (O) Rg, S (O) 2Rg, NRhS (O) 2Rg, S (O) 2NRhRi, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, or heterocycloalkenyl, wherein C1-6-alkyl is optionally substituted with one or more substituents selected from the group consisting of CN, halo, hydroxy, S (O) 2NH (C1-6-alkyl), C1-6-alkoxy, heterocycloalkyl, cycloalkyl, heteroaryl, aryl, -NH2, -NHCl-6-alkyl, and -N (C1-6 -alkyl) 2； wherein aryl, cycloalkyl, heteroaryl, or heterocycloalkyl, alone or as part of another moiety, is optionally substituted with one or more R7； R6, at each occurrence, is independently CN, NO2, halo, C3-8 cycloalkyl, ORj, SRj, C (O) Rj, C (O) NRkR1, C (O) ORj, NRkRl, NRkC (O) R
