LEE, Ju Young,RYU, Keun-Ho,KIM, Jae-Sun,KIM, Yong-Hyuk,SHIN, Dong Chul,LEE, Bong-yong,KANG, Sang-hwan,LEE, Hyun Jung,JUNG, Hoechul,SHIN, Young Ah,PARK, Euisun,AHN, Jaeseung,KIM, Hun-Taek,RYU, Je Ho
申请号：
ES12811865
公开号：
ES2671581T3
申请日:
2012.07.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I), a pharmaceutically acceptable salt or solvate thereof: ** Formula ** wherein, R 1 is phenyl, pyridyl or thienyl fused to a structural moiety which, together with two ring members of said phenyl , pyridyl or thienyl, forms a 5-7 membered aromatic or non-aromatic ring, wherein said ring optionally contains up to three heteroatoms independently selected from O, N and S, and the condensed phenyl, pyridyl or thienyl ring is optionally substituted with one or more groups independently selected from halo, -O-C1-6 alkyl, -S-C1-6 alkyl, -C1-6 alkyl, -haloalkyl C1-6, CN, - (CH2) p-OR4, -O - (CH2) q-NR4R5, - (CH2) p-NR4R5, -NHCO-O- (CH2) q-NR4R5, -NHCO- (CH2) p-NR4R5, or -C5-15 heteroaryl containing up to three selected heteroatoms regardless of O, N and S； or R 1 is phenyl or pyridyl optionally substituted with one or more groups independently selected from halo, -O-C 1-6 alkyl, -S-C 1-6 alkyl, - C 1-6 alkyl, -C 1-6 haloalkyl, -CN, - (CH2) p-OR4, -O- (CH2) q-NR4R5, -NH- (CH2) q-NR4R5, - (CH2) p-NR4R5, - (CH2) p- NHCOR4, - (CH2) p-NHCO2R4 , - (CH2) p-NHSO2R4 or -C5-15 heterocycle, said C5-15 heterocycle containing up to three heteroatoms independently selected from O, N and S and being optionally substituted with C1-6 alkyl； R2 is H, halo, -O-C1-6 alkyl, -S-C1-6 alkyl, -C1-6 alkyl, -C3-7 cycloalkyl, -C5-15 heteroaryl, -C 1-6 haloalkyl, - (CH2) p-OR4, -O- (CH2) p-NR4R5, - (CH2) p-NR4R5, CN, -CONHR4, or -SO2NHR4； R3 is H, -O-C1-6 alkyl, -S-C1-6 alkyl, -C1-6 alkyl, -C3-7 cycloalkyl, - (CH2) p-NR4R5, -O- (CH2) qNR4R5, - ( CH2) p- CON-HOH, - (CH2) p-CN, - (CH2) p-CO2R4, - (CH2) p-CONR4R5, - (CH2) p-tetrazole, - (CH2) p-COR4, - ( CH2) q- (OR6) 2, - (CH2) p-OR4, - (CH2) p-CH>； = CH-CN, - (CH2) p-CH>； = CH-CO2R4, - (CH2) p-CH >； = CH-CONR4R5, - (CH2) p-NHCOR4, - (CH2) p- NHCO2R4, - (CH2) p-NHSO2R4, or - (CH2) p-CH>； = CH-tetrazole； R4 and R5 are independently H or -C 1-6 alkyl； or R4 and R5, together with the nitrogen atom to which they are attached,
