SUN, ROBERT,MONOVICH, LAUREN G.,CHAMOIN, SYLVIE,WESTBROOK, JOHN
申请号：
ES10785061
公开号：
ES2472446T3
申请日:
2010.11.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula II: ** Formula ** wherein: R2 is OH, C2-7 alkenyloxy, C2-7 alkoxy, C6-10 aryl, C1-7 aryl-alkyl, C2-7 aryl-alkenyl, C2 alkenyl -7, C17 alkyl, C3-8 cycloalkyl, C2-7 alkynyl, heteroaryl, heteroaryl-C1-7 alkyl, -CH2C (O) OH, -CH2C (O) O-C1-7 alkyl, - CH2C (O) NH -C6-10 aryl, -CH2C (O) NH-heteroaryl, -CH2C (O) -heterocyclyl, -CH2C (O) NH-heterocyclyl, -CH2C (O) NHC 1-7 alkyl, -C (O) O-alkyl C1-7 or -C (O) - C1-7 alkyl； wherein aryl, heterocyclyl and heteroaryl are optionally substituted with one or more R6； R3 and R4 are independently selected from the group consisting of H, C1-7 alkyl, hydroxy, aryl-C1-7 alkyl or halo； wherein the aryl is optionally substituted with one or more R8； and R5 is H, halo, hydroxy or C2-7 alkenyl； and R6 and R8 for each occurrence, is independently C1-7 alkyl, C3-7 cycloalkyl, halo- C1-7 alkyl, CN, OH, NH2, C1-7 alkylamino, di- (C1-7 alkyl) amino, C6 aryl -10, heteroaryl, C1-7 alkoxy, halo, heterocyclyl, benzyloxy, halo- C1-7 alkoxy, -OS (O) 2-C1-7 alkyl or -OS (O) 2-halo C1-7 alkyl； wherein the C6-10 aryl, heterocyclyl and heteroaryl are optionally substituted with one or more R9； for each occurrence, R7 is independently hydrogen, C2-7 alkenyl, C1-7 alkyl, C3-8 cycloalkyl, halo, nitro, cyano, NH2, C1-7 haloalkyl, C1-7 alkoxy, C3-8 cycloalkoxy, C6- aryloxy 10, C6-10 aryl, heteroaryl, C6-10 aryl-C1-7 alkyl, heteroaryl-C1-7 alkyl, heterocyclyl, heterocyclyl-C1-7 alkyl, C (O) OR10 or N (R11R12), wherein said alkyl , alkenyl, alkoxy, aryl, heterocyclyl and heteroaryl each are optionally substituted with one or more substituents independently selected from C1-7 alkyl, hydroxy, halo, halo C1-7 alkyl, C1-7 alkoxy, nitro, cyano, C1- dialkylamino 7, C1-7 alkylamino and C17 alkoxy-C1-7 alkyl； R9 for each occurrence, is independently C1-7 alkyl, C1-7 alkoxy, halo, C1-7 haloalkyl, NH2, C1-7 alkylamino, di- (C1-7 alkyl) amino, C1-7 haloalkoxy, CN, OH, C (O) O-C 1-7 alkyl, C (O) O-C 1-7 haloalkyl, carbamoyl, C 1-7 alkylaminocarbonyl o
