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2- (Phenyl or pyrid-3-yl) aminopyrimidine derivatives as LRRK2 kinase modulators for the treatment of Parkinson's disease
专利权人:
F. Hoffmann-La Roche AG
发明人:
BAKER-GLENN, Charles,CHAMBERS, Mark,CHAN, Bryan K.,ESTRADA, Anthony,SWEENEY, Zachary
申请号:
ES12794308
公开号:
ES2592802T3
申请日:
2012.11.28
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula I: ** Formula ** or pharmaceutically acceptable salts thereof, wherein: m is 0 to 3; X is: -NRa-; -OR-; or -S (O) r-, in which r is from 0 to 2 and Ra is hydrogen or C1-6 alkyl; Y is C or N; R1 is: C1-6 alkyl; C2-6 alkenyl; C2-6 alkynyl; halo C1-6 alkyl; C1-6 alkoxy-C1-6 alkyl; C1-6 hydroxyalkyl; aminoC 1-6 alkyl, wherein the amino group is optionally substituted with one or two alkyl; C1-6 alkylsulfonyl-C1-6 alkyl; C3-6 cycloalkyl optionally substituted with C1-6 alkyl; C3-6 cycloalkyl-C1-6 alkyl wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; tetrahydrofuranoyl; tetrahydrofuranoyl-C 1-6 alkyl; oxetanyl; or oxetan-C1-6 alkyl; or R1 and Ra, together with the atoms to which they are attached, can form a three to six membered ring that can optionally include an additional heteroatom selected from O, N and S, and which is substituted with oxo, halo or C1 alkyl -6; R2 is: halo; C1-6 alkoxy; cyano; C2-6 alkynyl; C2-6 alkenyl; halo C1-6 alkyl; C1-6 haloalkoxy; C3-6 cycloalkyl, wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; C3-6 cycloalkyl-C1-6 alkyl, wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; tetrahydrofuranoyl; tetrahydrofuranoyl-C 1-6 alkyl; acetyl; oxetanyl; or oxetan-C1-6 alkyl; each of R3 and R4 is independently: halo; C1-6 alkyl; C1-6 alkoxy; C3-6 cycloalkyloxy; C1-6 haloalkyl; or haloC 1-6 alkoxy; and R5 is a 5-membered heteroaryl group optionally substituted one or more times with R6; and R6 is: C1-6 alkyl; C3-6 cycloalkyl; C3-6 cycloalkyl-C1-6 alkyl; halo; halo C1-6 alkyl; C1-6 alkoxy; heterocyclyl; oxo; or -C (O) -NRbRc, wherein each of Rb and Rc is independently hydrogen or -C 1-6 alkyl.Un compuesto de fórmula I:**Fórmula** o sales farmacéuticamente aceptables del mismo, en la que: m es de 0 a 3; X es: -NRa-; -O-; o -S(O)r-, en la que r es de 0 a 2 y Ra es hidrógeno o alquilo C1-6; Y es C o N; R1 es: alquilo C1-6; alquenilo C2-6; alquinilo C2
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