BARNES, David,CHOPRA, Rajiv,COHEN, Scott Louis,FU, Jiping,KATO, Mitsunori,LU, Peichao,SEEPERSAUD, Mohindra,ZHANG, Wei
申请号：
ES11715244
公开号：
ES2605039T3
申请日:
2011.04.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula I: ** Formula ** or a salt thereof, wherein R is C1-C6 alkyl, C1-C4 haloalkyl, or phenyl； R1 is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl or C1-C8 alkoxy C1-C12 alkyl, each of which is substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, cyano , CO2H, C (O) N (R1D) 2, N (R1A) S (O) 2R1B, N (R1A) C (O) R 1B, S (O) 2K1C, S (O) R1C, N (R1A) S (O) 2N (R1D) 2, N (R 1A) C (O) N (R1D) 2, OC (O) N (R1D) 2, N (R 1A) C (O) 2R1B, C (O) R1B, P (O) (R1E) 2, C (O) R1F, amino, mono- and di-C1-C4 alkylamino, C3-C6 cycloalkyl, phenyl, phenoxy, heteroaryl, heteroaryloxy, and heterocycle, whose heterocycle is saturated or partially unsaturated, It has one or two rings and 1 or 2 ring heteroatoms selected from N, O or S, and wherein each phenyl, phenoxy, heteroaryl and heteroaryloxy is unsubstituted or substituted with one to four groups independently selected from the group consisting of C1-C4 alkyl, CO2H, C (O) C1-C4 alkyl, C (O) 2 C1-C4 and halogen, and wherein the heterocycle and cycloalkyl substituents are unsubstituted or substituted with one to four groups independently selected from the group consisting of C1-C4 alkyl, CO2H, C (O) C1-C4 alkyl, C (O) 2 C1-C4 alkyl, oxo and halogen； R1A is independently selected at each occurrence from the group consisting of hydrogen, C1-C6 alkyl and C2-C6 alkenyl； R1B is independently selected at each occurrence of C1-C6 alkyl, CF3 or phenyl, whose phenyl is unsubstituted or substituted with one, two or three groups independently selected from C1-C4 alkyl, halogen, C1-C4 alkoxy, C1-C4 haloalkyl or C1-C4 haloalkoxy, in which R1A and R1B can be taken together to form a cycle； R1c is independently selected at each occurrence from the group consisting of C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C4 haloalkyl, mono- and di-C1-C4 alkylamino, or phenyl, which phenyl is unsubstituted or substituted with one or 2 C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, cyano, halogen, morpholino
