LEFKER, BRUCE,BRODNEY, MICHAEL,SAKYA, SUBAS,HAY, BRUCE,WESSEL, MATTHEW,CONN, EDWARD
申请号：
ES07789659
公开号：
ES2373587T3
申请日:
2007.08.13
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
1. A compound of Formula I or Formula II, ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is hydrogen or a C1-C6 alkyl group； R2 is a 4-15 membered heterocycloalkyl, optionally substituted with one or more substituents selected from the group R7； wherein R3 is hydrogen or C1-C6 alkyl； wherein R4 is halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy or C1-C6 haloalkoxy； wherein R7 is independently selected from -OH, halogen, -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -C1-C6 alkoxy, -C2-C6 alkenoxy, -C2-C6 alkynoxy, - C1-C6 hydroxyalkyl, -CN, -NO2, -NR8R9, -C (= O) N8R9, -C (= O) R8, - O (= O) OR8, -S (O) 2NR8R9, -S (O) nR8, -NR9C (= O) R8, -NR9SO2R8, - (Ccero-C6 alkylene) -C6-C15 aryl, - (Ccero-C6 alkylene) -heterocycloalkyl (5-15 members), - (Ccero-C6 alkylene) - heteroaryl (5-15 members), - (Ccero-C6 alkylene) -C6-C15 aryloxy and - (Ccero-C6 alkylene) -heteroaryloxy (5-15 members), wherein said alkyl, alkenyl, alkynyl, alkoxy, alkenoxy , alkyloxy, hydroxyalkyl, aryl, aryloxy, heteroaryl and heteroaryloxy of R7 are each optionally substituted independently with one or more substituents selected from halogens, -C1-C12 alkyl, -C1-C4 alkoxy, -NR8R9, -C (= O) N8R9, -C (= O) R8, -C (= O) OR8, -NR9C (= O) R8, - NR9SO2R8, -S (O) 2NR8R9, -S (O) nR8 or -ON； each R8 and R9 are independently selected from -H, -C1-C15 alkyl, -C2-C15 alkenyl, -C2-C15 alkynyl, - (Ccero-C4 alkylene) - (C3-C15 cycloalkyl), - (Ccero-C4 alkylene ) - (C4-C6 cycloalkenyl), - (Ccero-C4 alkylene) - (heterocycloalkyl (5-15 members), - (Ccero-C4 alkylene) - (C6-C15 aryl) and - (Ccero-C4 alkylene) - ( heteroaryl (5-15 members)), wherein said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl of each of R8 and R9 is optionally substituted independently with one or more substituents independently selected from -OH, -C1-C12 alkyl, -C2-C12 alkenyl, -C2-C12 alkynyl, C1-C6 alkoxy, -C2-C6 alkynoxy, -C2-C6 alkyloxy, C1-C6 hydroxyalkyl, ha
