MATHEWS, Christopher,FINNEY, John,SCUTT, James,ROBINSON, Louisa,DELANEY, John
申请号：
ES10701333
公开号：
ES2587627T3
申请日:
2010.01.06
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I ** Formula ** in which A is pyridyl, pyrazinyl, pyrimidinyl, pyridacinyl, benzothiazolyl, benzoxazolyl, cinolinyl, quinolinyl, quinazolinyl, quinoxalinyl or benzotriacinyl, in each case substituted by halogen, methyl, ethyl, trifluoromethyl methoxy, difluoromethoxy, trifluoromethoxy, nitro or cyano； R1 is methyl, ethyl, n-propyl, isopropyl, cyclopropyl, halomethyl, haloethyl, vinyl, propenyl, ethynyl, propynyl, halogen, methoxy, ethoxy, halomethoxy or haloethoxy； R2 and R3 are independently from each other hydrogen, methyl, ethyl, n-propyl, isopropyl, cyclopropyl, halomethyl, haloethyl, vinyl, propenyl, ethynyl, propynyl, halogen, methoxy, ethoxy, halomethoxy or haloethoxy； and R4, R5, R6 and R7 are independently from each other hydrogen, C1-C6 alkyl, C1-C6 alkyl substituted with C1-C4 alkoxy or halogen, C2-C6 alkenyl, C2-C6 alkenyl substituted with C1-C4 alkoxy or halogen , C2-C6 alkynyl, C2-C6 alkynyl substituted with C1-C4 alkoxy or halogen, C3-C7 cycloalkyl, C3-C7 cycloalkyl substituted with C1-C4 alkyl or C1-C4 alkoxy, C5-C7 cycloalkenyl, substituted C5-C7 cycloalkenyl with C1-C4 alkyl or C1-C4 alkoxy, or heterocyclyl or heterocyclyl substituted with C1-C4 alkyl or C1-C4 alkoxy； or R4 and R5, or R6 and R7, together with the atoms to which they are attached, form a 5- to 8-membered spirocarbocyclyl or spiroheterocyclyl, wherein the spiroheterocyclyl contains one or two heteroatoms selected from nitrogen, oxygen and sulfur； or R5 and R6, together with the atoms to which they are attached, form a 5- to 8-membered carbocyclyl or heterocyclyl, wherein the heterocyclyl contains one or two heteroatoms selected from nitrogen, oxygen and sulfur； and Y is O, S (O) n, C>； = O, CR8R9 or CR10R11CR12R13； n is 0, 1 or 2； and R8 and R9 are independently of each other hydrogen, C1-C6 alkyl, C1-C6 alkyl substituted with C1-C4 alkoxy or halogen, C2-C6 alkenyl, C2-C6 alkenyl substituted with C1-C4 alkoxy or halogen, C2 alkynyl C6, C2-C6 alkynyl substitute
