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4-ARIL-1,4-DIHIDRO-1,6-SUBSTITUTED NAFTIRIDINS AND THEIR USE.
专利权人:
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT;BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
FIGUEROA PEREZ, SANTIAGO,KOLKHOF, PETER,BAERFACKER, LARS,FLAMME, INGO,SCHLEMMER, KARL-HEINZ,GROSSER, ROLF,MUENTER, KLAUS,KNORR, ANDREAS,NITSCHE, ADAM
申请号:
ES07725745
公开号:
ES2372626T3
申请日:
2007.06.01
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compound of formula (I) in which Ar represents a group of formula in which * means the binding site, R5 means hydrogen or halogen, R6 means methyl or ethyl, R7 means hydrogen, fluorine, chlorine, cyano, nitro, trifluoromethyl or (C1-C4) alkyl, R8 means hydrogen or fluorine, R9 means halogen, (C1-C4) alkyl, trifluoromethyl, (C1-C4) alkoxy or trifluoromethoxy, R10 means cyano or nitro, R11 means hydrogen, halogen, alkyl ( C1-C4), (C1-C4) alkoxy, (C1-C4) alkylthio or di (C1-C4) -amino alkyl, the alkyl group may be substituted in the (C1-C4) alkyl, (C1-) alkoxy moieties C4) and alkylthio (C1-C4) mentioned respectively up to three times with fluorine, or means phenyl, which may be substituted with halogen, (C1-C4) alkyl or trifluoromethyl, R12 means hydrogen, halogen or (C1-C4) alkyl, D means CH, C-R9 or N and n means the number 0, 1 or 2, and its meanings may be the same or different for the case in which the R9 substituent appears several times, R1 represents cyano, nitro or a group of formula -C (= O) -R13, in which R13 means (C1-C6) alkyl, which may be substituted with cycloalkyl (C3-C7) or of one to three times with fluorine, or means phenyl, which may be substituted with halogen, cyano, (C1-C4) alkyl, trifluoromethyl, (C1-C4) alkoxy or trifluoromethoxy, or means (C3-C7) cycloalkyl, R2 represents alkyl (C1-C4), trifluoromethyl, cyclopropyl, cyclobutyl, (C1-C4) alkoxy or (C1-C4) alkyl, R3 represents (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethoxy, (C1-C6) alkylthio , amino, mono (C1-C6) alkyl-amino or a group of formula -O-SO2-R14, the alkyl (C1-C6), alkoxy (C1-C6) and alkylthio (C1-C6) moieties being substituted mentioned respectively with (C3-C7) and R14 cycloalkyl means (C1-C6) alkyl, trifluoromethyl, (C3-C7) cycloalkyl, 5 or 6 membered phenyl or heteroaryl with up to two N, O and / or S series heteroatoms , may be substituted on the other hand, phenyl and heteroaryl, respectively, once or twice, in the same or different manner, with halogen, cyano, nitro, (C1-C4)
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