BUTLER, Rebecca,LEBLANC, Catherine,MCKEOWN, Stephen Carl,CHARLTON, Steven John
申请号：
ES14707841
公开号：
ES2637719T3
申请日:
2014.02.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound represented by Formula Ia ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein R1 is -X-Y； or -W-R7-X-Y； R2 is H, C1-C8 alkyl optionally substituted with one or more halogen atoms, C1-C4 alkyl, OH, or OR '； R2a is hydrogen； or 10 R2 and R2a taken together are oxo； R3 is H, C1-C4 alkoxy, OH, -NR19R21, CN, halogen, C3-C7 cycloalkyl or C1-C4 alkyl optionally substituted with one or more halogen atoms； R4 is H, C1-C4 alkoxy, OH, -NR19R21, CN, halogen, C3-C7 cycloalkyl or C1-C4 alkyl optionally substituted with one or more halogen atoms； R5 is C1-C8 alkyl optionally substituted with one or more halogen atoms, C1-C4 alkyl, OH, OR ', -NR19R21, CN or C3-C7 cycloalkyl； C1-C8 alkyl optionally substituted with one or more halogen atoms, C6-C14 aryl； - (C0-C4 alkyl) 4 to 14 membered heteroaryl or - (C0-C4 alkyl) 3 to 14 membered heterocyclyl in which the heteroaryl and heterocyclyl contain at least one heteroatom selected from N, O and S, wherein aryl, heteroaryl and heterocyclyl are each optionally substituted with one or more Z substituents； R6 is C6-C14 aryl； - (C0-C4 alkyl) 4 to 14 membered heteroaryl or - (C0-C4 alkyl) 3 to 14 membered heterocyclyl in which the heteroaryl and heterocyclyl contain at least one heteroatom selected from N, O and S, wherein aryl, heteroaryl and heterocyclyl are each optionally substituted with one or more Z substituents； W is C1-C6 alkylene optionally substituted with hydroxy, halogens or C1-C4 alkyl； X is C1-C6 alkylene optionally substituted with hydroxy, halogens or C1-C4 alkyl； Y is -C (O) OH, -C (O) ORx, tetrazolyl, carbamoyl, monoalkylcarbamoyl, dialkylcarbamoyl or -CONH-S (O) q-Rx, wherein Rx is -C1-C4 alkyl； Z is independently OH, aryl, O-aryl, benzyl, O-benzyl, C1-C6 alkyl optionally substituted with one or more OH groups or NH2 groups, C1-C6 alkyl optionally substituted with one or more halogen atoms, C1-C6 alkoxy optionally substituted with one or more OH groups, C1-C6 alkoxy optionally substituted w
