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Imidazo [1,2-a] pyridines substituted with 3-aryl and their use
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
VAKALOPOULOS, Alexandros,FOLLMANN, Markus,HARTUNG, Ingo,BUCHGRABER, Philipp,GROMOV, Alexey,LINDNER, Niels,WUNDER, Frank,STASCH, Johannes-Peter,REDLICH, Gorden,LI, Volkhart Min-Jian
申请号:
ES14727828
公开号:
ES2625744T3
申请日:
2014.06.04
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I) ** Formula ** in which A represents CH2, CD2 or CH (CH3), R1 represents cycloalkyl (C3-C7), phenyl or pyridyl, and cycloalkyl (C3-C7) can be substituted with 1 to 4 substituents independently selected from each other from the fluorine, trifluoromethyl and (C1-C4) alkyl group, with phenyl being substituted with 1 to 4 substituents independently selected from each other from the halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C1-C4) alkyl group ), (C1-C4) alkoxy and difluoromethoxy, and pyridyl being substituted with 1 or 2 substituents independently selected from the group of halogen, cyano and (C1-C4) alkyl, R2 represents (C1-C4) alkyl, cyclopropyl, monofluoromethyl , difluoromethyl or trifluoromethyl, R3 represents 5 to 10 membered phenyl or heteroaryl, phenyl may be substituted with 1 to 3 substituents independently selected from the group of halogen, cyano, trifluoromethyl, difluoromethyl, alkyl (C1-C6), alkyl- (C1-C4) -carbonyl, alkoxy- (C1-C4) -carbonyl, hydroxycarbonyl, - (C>; = O) NR7R8, alkyl- (C1-C4) -sulfonyl, cycloalkyl- ( C3-C6) -sulfonyl, alkylthio- (C1-C4), alkoxy (C1-C4), trifluoromethoxy, difluoromethoxy, phenoxy, hydroxy and cycloalkyl (C3-C7), where (C1-C6) alkyl can be substituted with 1 or 2 substituents selected from the group of fluorine, trifluoromethoxy, alkyl- (C1-C4) -carbonyl, - (C>; = O) NR7R8, alkoxy (C1-C4), cycloalkyl (C3-C6), morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, hydroxy and amino, amino may be substituted with 1 or 2 substituents independently selected from each other of (C1-C6) alkyl, alkyl- (C1-C4) -carbonyl, cycloalkyl- (C3-C6) -sulfonyl, alkyl- ( C1-C4) -sulfonyl and methoxy-C1-C4 alkyl, and wherein cycloalkyl (C3-C6) may be substituted with amino or hydroxy, in which R7 and R8 in each case independently represent hydrogen, alkyl ( C1-C4) or cycloalkyl (C3-C7), heteroaryl may be substituted 5 to 10 members with 1 to 3 substituents independently selected from the group
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