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Oxadiazole derivatives as S1P1 agonists
专利权人:
ASTELLAS PHARMA INC.
发明人:
HARADA, HIRONORI,HATTORI, KAZUYUKI,FUJITA, KAZUYA,MORITA, MASATAKA,IMADA, SUNAO,ABE, YOSHITO,ITANI, HIROMICHI,MOROKATA, TATSUAKI,TSUTSUMI, HIDEO
申请号:
ES07740850
公开号:
ES2453372T3
申请日:
2007.04.02
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, where the symbols have the following meanings; Ring A is: [Chemical formula 6] X is a single bond, -CH2-, -NR3-, 10 -O-, -S-, -S (>; = O) -, or -S (>; = O2) -; R1 is halogen, aryl, heteroaryl, cycloalkyl (C3-C8), cycloalkenyl (C3-C8), heterocycloalkyl (C3-C8), or alkyl (C1-C6) or alkenyl (C2-C6), each of which can contain halogen, -CONH2, aryl or cycloalkyl (C3-C8), as a substituent; R2 is -CN, -O-(C1-C6) alkyl, -C (>; = O) H, halogen or (C1-C6) alkyl which may be substituted with halogen or -OH; R3 is -H, where R3 can form morpholino, 1-pyrrolidinyl or 3,4-dehydropyperin-1-yl, together with R1 and nitrogen, where, when -X- is a single bond, R1 and R2 can form a combination 5-membered ring and also contain (C1-C6) alkyl as substituent; R4 is where any one of the R4 ring bonds is attached to the oxadiazole ring, R5 is -H; R0-C1-C6 alkyl -, R0-C1-C6 alkyl -O-, R0-C1-C6 alkyl-C (>; = O) -, R0-C1-C6 alkyl -S ( >; = O) 2-, R0-O-(C1-C6) alkyl -, R0-C (>; = O) - (C1-C6) alkyl -, R0-S (>; = O) 2-(C1-) alkyl C6) -, (C2-C6) alkenyl -, -C (>; = O) H, -ORX, -S (>; = O) 2RX, halogen,>; = O, -NRXRY, -C (>; = O) NRXRY ; where R0 is -CN, -C (>; = O) NRX RY, -NHRX, -SRX, -S (>; = O) 2RX and -ORX; RX and RY may be the same or different from each other, and are -H, or (C1-C6) alkyl which may be substituted with -OH, -NH2 which may be protected with a protective group or heteroaryl, where RX may form heterocycloalkyl ( C3-C8), together with RY or nitrogen.Un compuesto representado por la fórmula (I): o una sal farmacéuticamente aceptable del mismo, donde los símbolos tienen los siguientes significados; el anillo A es: [Fórmula química 6] X es un enlace simple, -CH2-, -NR3-, 10 -O-, -S-, -S(>;=O)-, o -S(>;=O2)-; R1 es halógeno, arilo, heteroarilo, cicloalquilo (C3-C8), cicloalquenilo (C3-C8), heterocicloalquilo (C3-C8), o alquilo (C1-C6) o alquenilo (C2-C6), cada uno d
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