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Isotiazoles sustituidos con amino
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
BÄRFACKER, Lars,PRECHTL, Stefan,SIEMEISTER, Gerhard,WENGNER, Antje Margret,ACKERSTAFF, Jens,NOWAK-REPPEL, Katrin,BADER, Benjamin,LIENAU, Philip,STÖCKIGT, Detlef,HEINRICH, Tobias
申请号:
ES14701566
公开号:
ES2634014T3
申请日:
2014.01.28
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I) ** (See formula) ** in which: A represents a heteroaryl group selected from: ** (See formula) ** in which one of X1, X2 and X3 represents N, O or S as a ring atom and the other of X1, X2 and X3 represent carbon as ring atoms, and wherein X4, X5, X6 and X7 represent carbon as ring atoms or one of X4, X5, X6 and X7 represents an N atom, and the other of X4, X5, X6 and X7 represent carbon as ring atoms, and wherein X1 and X2 or X2 and X3 or X4 and X5 or X5 and X6 or X6 and X7 optionally form part of a 5- membered or 6 additional members, optionally containing an additional heteroatom selected from the group consisting of O, N and S, and which ring is unsaturated or partially saturated, and wherein * indicates the point of attachment of said groups with the rest of the molecule, said heteroaryl group, which is monocyclic or bicyclic, is optionally substituted, once or twice, identically or dif erente with a substituent selected from: C1-C6 alkyl, C1-C6 haloalkyl, C1-C6alkoxy, C3-C6cycloalkyl, C3-C6 cycloalkyloxy, hydroxy, a halogen atom, cyano, phenyl, 5-membered heteroaryl, COOR3 , CONR4R5, NR4R5, said phenyl and 5-membered heteroaryl are optionally substituted, once or twice, identically or differently, with a substituent selected from: a halogen atom, or a C1-C3 or C1-C3 R1 represents a C1-C3 alkyl, R2 represents a group selected from:, once or twice, identically or differently, with a substituent selected from phenyl or pyridinyl, wherein said phenyl and pyridinyl are optionally substituted: C1-C6 , C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy, hydroxy, a halogen atom, phenyl, phenyloxy, said phenyl and phenyloxy optionally substituted, once or twice , identically or differently, with s ustituyente selected from: a halogen atom, or a C1-C3 or C1-C3 alkyl, R3 represents: a hydrogen atom, or a group selected from C1-C6 alkyl, R4 represents: a hydrogen atom, or group selected from C1-C6 alkyl, R5 repre
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