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New amide derivative and its use as medicine
专利权人:
Mitsubishi Tanabe Pharma Corporation
发明人:
MAEDA, Kazuhiro,ENDOH, Jun-ichi,TARAO, Akiko,TASHIRO, Kaoru,ISHIBUCHI, Seigo,HIKAWA, Hidemasa
申请号:
ES11775073
公开号:
ES2653966T3
申请日:
2011.04.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
An amide derivative represented by the following formula (I) ** Formula ** where A is a 6-membered phenylene or heteroarylene represented by the following formula ** Formula ** where Z4, Z5, Z6 and Z7 each is a carbon atom or a nitrogen atom, these phenylene and heteroarylene are optionally substituted with one or the same or different 2 or 3 substituents selected from a halogen atom; a hydroxyl group; nitro; cyano; mercapto; C1-C6 alkyl optionally substituted with amino optionally mono- or di-substituted with C1-C6 alkyl, a halogen atom, a hydroxyl group or C1-C6 alkoxy; C2-C6 alkenyl; C2-C6 alkynyl; C3-C6 cycloalkyl optionally substituted with a halogen atom, a hydroxyl or amino group; C6-C10 aryl optionally substituted with substituent B shown below; heteroaryl containing 1-6 atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom and having 5-10 atoms that constitute the ring, which is optionally substituted with a substituent B shown below; C1-C6 alkoxy optionally substituted with amino optionally mono- or di-substituted with C1-C6 alkyl, a halogen atom, a hydroxyl group or C1-C6 alkoxy; C2-C7 acyloxy; C1-C6 alkylthio wherein the alkyl moiety is optionally substituted by a halogen atom or a hydroxyl group; C1-C6 alkylsulfinyl wherein the alkyl moiety is optionally substituted by a halogen atom or a hydroxyl group; C3-C6 cycloalkylthio; C3-C6 cycloalkylsulfinyl; C3-C6 cycloalkylsulfonyl; amino optionally mono- or di-substituted with C1-C6 alkyl or C3-C6 cycloalkyl; C2-C7 acylamino wherein the amino moiety is optionally substituted by C1-C6 alkyl; aminocarbonyl wherein the amino moiety is optionally mono- or di-substituted with C1-C6 alkyl or C3-C6 cycloalkyl; C1-C6 alkylsulfonylamino wherein the amino moiety is optionally substituted by C1-C6 alkyl; C3-C6 cycloalkylsulfonylamino wherein the amino moiety is optionally substituted by C1-C6 alkyl; a non-aromatic heterocyclic group containing 1-4 atoms selected from a nitrogen atom, an oxygen atom and
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