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Compound capable of binding the S1P receptor and pharmaceutical use thereof
专利权人:
LTD.;ONO PHARMACEUTICAL CO.
发明人:
Nakade, Shinji,Mizuno, Hirotaka,Ono, Takeji,Minami, Masashi,Saga, Hiroshi,Hagiya, Hiroshi,Komiya, Takaki,Habashita, Hiromu,Kurata, Haruto,Ohtsuki, Kazuhiro,Kusumi, Kensuke
申请号:
ES14190717
公开号:
ES2754221T3
申请日:
2004.08.27
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
A compound represented by the formula (I-S-7a): ** Formula ** in which ring A represents a C3-15 carbocyclic group; X represents a bond or a divalent group having 1 to 8 atoms in its backbone having 1 to 4 combinations selected from C1-8 alkylene that can be substituted, C2-8 alkenylene that can be substituted, a nitrogen atom that it can be substituted, (-NH-), -CO-, -O-, C3-6 cycloalkylene that can be substituted and phenylene that can be substituted; n represents 0 or 1, where when n is 0, m is 1 and R1 represents a hydrogen atom or a substituent, and when n is 1, m is 0 or an integer from 1 to 7 and R1 represents a substituent on where when m is 2 or more, the various R1 are the same or different; the substituent represented by R1 is fluorine, chlorine, bromine, methyl, trifluoromethyl or methoxy; the substituent on "which may be substituted" is selected from C1-20 alkyl, C2-20 alkenyl, C2-20 alkynyl, C1-20 alkylidene, a cyclic group, C1-20 alkyl substituted with a cyclic group, oxo, hydroxy , C1-20 alkyloxy, C2-20 alkenyloxy, C2-20 alkynyloxy, hydroxy which may be protected by a cyclic group, C1-20 acylthio, thioxo, mercapto, C1-20 alkylthio, C2-20 alkenylthio, C2-20 alkynylthio, mercapto substituted with a cyclic group, C1-20 alkylsulfinyl, C2-20 alkenylsulfinyl, C2-20 alkynylsulfinyl, sulfinyl substituted with a cyclic group, C1-20 alkylsulfonyl, C2-20 alkenylsulfonyl, sulfonyl substituted with a cyclic group , C1-20 alkylsulfonyl substituted with a cyclic group, sulfino, sulfo, sulfamoyl, carboxy, C1-20 acyl, C1-20 acyl substituted with a cyclic group, carbonyl substituted with a cyclic group, carbamoyl, cyano, amidino, nitro, nitroso , imino, amino, and a halogen atom; RS0, RS1, RS2, RS3, RS4, RS5 and RS6 each independently represent a hydrogen atom, a halogen atom or C1-4alkyl which may be substituted with 1 to 3 halogen atoms, RS12, RS13, RS14 and RS15 each independently represents a hydrogen atom, a halogen atom or C1-4alkyl which may be substituted with
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