BEJKER-GLENN Charlz (GB),БЕЙКЕР-ГЛЕНН Чарльз (GB),BERDIK Daniel Dzhon (US),БЁРДИК Даниэль Джон (US),CHEMBERS Mark (GB),ЧЭМБЕРС Марк (GB),CHAN Brajan K. (US),ЧАНЬ Брайан К. (US),CHEN Khuejfen (US),ЧЭНЬ,BEJKER-GLENN Charlz,БЕЙКЕР-ГЛЕНН Чарльз,BERDIK Daniel Dzhon,БЁРДИК Даниэль Джон,CHEMBERS Mark,ЧЭМБЕРС Марк,CHAN Brajan K.,ЧАНЬ Брайан К.,CHEN Khuejfen,ЧЭНЬ Хуэйфэнь,ESTRADA Entoni,ЭСТРАДА Энтони,GANZN
申请号：
RU2014124950
公开号：
RU0002661197C2
申请日:
2012.11.28
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to novel compounds of formula I and formula II or pharmaceutically acceptable salts thereof, having the properties of a leucine repeat kinase inhibitor 2 (LRRK2, id est "Leucine Rich Repeat Kinase"). Compounds of formula I and formula II correspond to structuresorIn the compound of formula I, m is 0, 1 or 2； X is -NRa- or -O-, and Ra represents a hydrogen atom or C1-6alkyl； R1 is C1-6alkyl or C3-6cycloalkyl optionally substituted with a halogen atom, or, if X is NH, R1 is deuterated C3-6cycloalkyl； or R1 and Ra together with the atoms to which they are attached, can form a three-six-membered ring； R2 is a halogen atom, cyano or halo-C1-6alkyl； R3 is -OR4, a halogen atom or C1-6alkyl； R4 is a hydrogen atom, C1-6alkyl, halogen-C1-6alkyl, C3-6cycloalkyl or C3-6cycloalkyl-C1-6alkyl； R5 is a hydrogen atom or C1-6alkyl； R6 is a hydrogen atom, C1-6alkyl, hydroxy-C1-6alkyl, C3-6cycloalkyl-C1-6alkyl, optionally substituted with hydroxy, 5-6 membered heteroaryl or heterocyclyl with 1 to 2 nitrogen atoms as ring heteroatoms； where heteroaryl and heterocyclyl each may be optionally substituted with C1-6alkyl； or R5 and R6 together with the nitrogen atom to which they are attached, form a four-seven-membered ring, optionally including an additional heteroatom selected from O and N, and optionally substituted with one or two groups independently selected from the following groups: C1-6alkyl, C1-6alkoxy, halogen-C1-6alkoxy, C1-6alkoxy-C1-6alkyl, hydroxy-C1-6alkyl, halogen atom, C3-6cycloalkyl-C1-6alkyl and 4-6 membered heterocyclyl with 1 to 2 heteroatoms selected from N and O； or R5 and R6 together with the nitrogen atom to which they are attached, and an additional heteroatom O form a deuterated morpholino group； or hexahydro-pyrrolo [1,2-a]pyrazinyl, 8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl, 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 1-oxa-6-aza-spiro[3.3]hept-6-yl or 2-oxa-6-aza-spiro[3.3]hept-6-yl； and R7 is a hydroxy group, a halogen atom, C
