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Phenyl derivative
专利权人:
LTD.;ONO PHARMACEUTICAL CO.
发明人:
Naganawa, Atsushi,Kusumi, Kensuke,Otsuki, Kazuhiro,Sekiguchi, Tetsuya,Kakuuchi, Akito,Shinozaki, Koji,Yamamoto, Hiroshi,Nonaka, Shigeyuki
申请号:
ES16002350
公开号:
ES2689132T3
申请日:
2012.09.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound represented by the general formula (I-1): ** Formula ** where R1 represents (1) a C1-8 alkyl group which may be substituted with 1 to 5 R21 groups, (2) a C2-8 alkenyl group which may be substituted with 1 to 5 R21 groups, (3) a C2-8 alkynyl group that may be substituted with 1 to 5 R21 groups, (4) a C3-7 carbocycle that may be substituted with 1 to 5 substituents selected from the group consisting of a C1-4 alkyl group, a C1-4 haloalkyl group, a C1-4 alkoxy group and a halogen atom, or (5) -CONR31R32; R21 represents (1) a halogen atom, (2) -OR22 (in the group, R22 represents (1) a hydrogen atom, (2) a C1-4 alkyl group or (3) a C1-4 haloalkyl group) , (3) -NR23R24 (in the group, R23 and R24 each independently represent (1) a hydrogen atom or (2) a C1-4 alkyl group) or (4) an oxo group; R31 and R32 independently represent each (1) a hydrogen atom or (2) a C1-4 alkyl group; R2 represents (1) a hydrogen atom, (2) a C1-4 alkyl group or (3) a C1-4 haloalkyl group; R3 and R4 each independently represent (1) a halogen atom, (2) a C1-4 alkyl group, (3) a C1-4 haloalkyl group, (4) a C1-4 alkoxy group, (5) a group hydroxy, (6) -L-CONR6R7, (7) -L-SO2R8 or (8) -LCOOR 9; R5 represents (1) a halogen atom, (2) a C1-4 alkyl group or (3) a C1-4 haloalkyl group; L represents (1) a bond, (2) a group represented by the formula: ** Formula ** in which A represents (1) a bond or (2) an oxygen atom; R12 and R13 each independently represent (1) a hydrogen atom, (2) a C1-4 alkyl group, (3) a hydroxy group or (4) NH2 or (5) R12 and R13 together with the carbon atom at which are attached can form a C3-7 carbocycle; and the arrow on the right side joins -CONR6R7, -SO2R8 or -COOR9, (3) a C2-4 alkenylene group, (4) a -O-C2-4 alkenylene group, (5) an oxygen atom or (6) a nitrogen atom that may be substituted with a C1-4 alkyl group; R6 and R7 each independently represent (1) a hydrogen atom, (2) a C1-4 alkyl group, (3) a C1-4 haloalkyl group, (4) a hydroxy group, (5) -CONR15R16, (6 ) -S
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