ABBOT Sara S. (US),АББОТ Сара С. (US),BOJS Dzheneviv N. (US),БОЙС Дженевив Н. (US),BJuTTEL'MANN Bernd (US),БЮТТЕЛЬМАНН Бернд (US),GOLDSTEJN Dejvid Majkl (US),ГОЛДСТЕЙН Дейвид Майкл (US),GON Leji (US),ABBOT SARA S.,BOJS DZHENEVIV N.,BJUTTELMANN BERND,GOLDSTEJN DEJVID MAJKL,GON LEJI,ГОН Лейи (US),KHOGG DZHOAN
申请号：
RU2009146124/04
公开号：
RU0002466993C2
申请日:
2008.05.13
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to novel derivatives of dihydroquinone and dihydronaphthyridinone of formula (I) or to its pharmaceutically acceptable salts, in which X represents group CR11 or N； Y represents group -C(O)R3, oxazolyl or isoxazolyl； Z represents phenyl, pyrrolidinyl, piperidinyl, morpholinyl, tetrahydropyranyl, pyridinyl, pyrimidinyl or pyrazolyl, and is substituted with groups R1 and R2； R1 and R2 each independently represents H, halogen, CN group, C1-6alkyl or group -Y1-Y2-Y3-R8, or R1 and R2 together form group -O(CH2)nO-, where n represents 1 or 2； Y1 represents group -O-, -C(O)-, -C(O)O-, -C(O)NR9-, -NR9C(O), -S-, -SO2- or bond； Y2 represents heterocycloalkylene, C1-6alkylene or bond, where heterocycloalkylene stands for cycloalkylene group, in which one, two carbon atoms are substituted with heteroatoms O or N, where heterocycloalkylene group also contains, at least, two carbon atoms and cycloalkylene represents ； Y3 represents group -O-, -C(O)-, -C(O)O-, -C(O)NR9-, -NR9C(O)-, -SO2- or bond； R8 represents H, C1-6alkyl, C1-6alkoxy, cyclohexyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, tetrahydropyranyl, or group -NR9R10, where R8, different from H, is optionally substituted with C1-6alkyl, halogen, group -CF3 or group -OH； R9 and R10 each independently represents H or C1-6alkyl； R3 represents OH, C1-6alkyl, C1-6alkoxy, (C1-6alkoxy)-C1-6alkoxy； R4 represents C1-6alkyl, phenyl, cyclopropyl, cyclobutyl, cyclobutyl, cyclohexyl, tetrahydropyranyl or tetrahydrothiophene 1,1 -dioxide, and is optionally substituted with C1-6alkyl, hydroxyl group, C1-6alkoxy, halogen, nitro group, amino group, cyano group or halo-lower alkyl； R5 and R6 each independently represents H, halogen, C1-6alkyl, group -CF3, C1-6alkoxy； R7 represents H； R11 represents H. Invention also re4lates to pharmaceutical composition based on formula (I) compound.EFFECT: obtained are novel dihydroquinone and dihydronaphthyridinone derivatives, useful for treatment
