AEBI, JOHANNES,BINGGELI, ALFRED,GREEN, LUKE,HARTMANN, GUIDO,MAERKI, HANS P.,MATTEI, PATRIZIO,RICKLIN, FABIENNE,ROCHE, OLIVIER
申请号：
ES08774212
公开号：
ES2377423T3
申请日:
2008.06.23
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compounds of formula (I) in which it is heterocyclyl, which is a non-aromatic monocyclic radical of four to eight ring atoms, in which one or two atoms in the ring are nitrogen atoms, and the remaining atoms in the ring they are carbon atoms； E is N or CH, as long as R1 or R2 can join C, replacing H； R1 and R2 are independently hydrogen, halogen, C1-6 alkoxy, C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkoxy or optionally substituted heterocyclyl； provided that one of R1 and R2 is not hydrogen； R3 and R4 are independently hydrogen, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy or halogen； R 5 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl or C 3-7 cycloalkyl-C 1-6 alkyl； R6 is hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 trimethylsilylalkyl, heteroalkyl, C2-6 alkenyl, C2-6 alkynyl, C2-6 hydroxyalkenyl, C2-6 hydroxyalkynyl, C1-6 alkoxy-C2-6 alkenyl , C 1-6 alkoxy-C 2-6 alkynyl, C 2-6 trimethylsilylalkyl, C 2-6 trimethylsilylalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, heteroalkoxy, C 3-7 cycloalkyl optionally substituted, C 3-7 cycloalkyl optionally substituted, halogen, cyano, optionally substituted phenyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted phenyl-methoxy-C 1-6 alkyl； m is 0, 1, 2, 3 or 4； R7 is, when attached to a ring carbon atom, independently hydrogen, C1-6 alkyl, C1-6 haloalkyl, heteroalkyl, C2-6 alkenyl, C2-6 alkynyl, C2-6 hydroxyalkenyl, C2-6 hydroxyalkynyl, alkoxy C1-6 C2-6 alkenyl, C1-6 alkoxy-C2-6 alkynyl, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy, heteroalkoxy, halogen, cyano, optionally substituted phenyl, optionally substituted C3-7 cycloalkyl, C3- cycloalkyl Optionally substituted 7-C 1-6 alkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted C 1-6 phenylalkyl, optionally substituted C 1-6 heteroarylalkyl, optionally substituted C 1-6 heterocyclylalkyl, nitro, carboxy, formyl, acyl, C 1-6 alkoxycarbonyl , carbamoyl, aminocarbonyl substituted with mono- or di- C1
