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Phenyl derivative
专利权人:
Ltd.;ONO Pharmaceutical Co.
发明人:
KUSUMI, Kensuke,NAGANAWA, Atsushi,OTSUKI, Kazuhiro,SEKIGUCHI, Tetsuya,SHINOZAKI, Koji,YAMAMOTO, Hiroshi,YAMAMOTO, Yasuko
申请号:
ES14775353
公开号:
ES2671559T3
申请日:
2014.03.25
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound represented by the general formula (I): ** Formula ** in which R1 represents (1) a C1-8 alkyl group which may be substituted with 1 to 5 R21 groups, (2) a C2-8 alkenyl group which may be substituted with 1 to 5 R21 groups, (3) a C2-8 alkynyl group which may be substituted with 1 to 5 R21 groups or (4) a C3-7 carbocycle which may be substituted with 1 to 5 substituents selected from group consisting of a C1-4 alkyl group, a C1-4 haloalkyl group, a C1-4 alkoxy group and a halogen atom; R21 represents (1) a halogen atom, (2) OR22 (in the group, R22 represents (1) a hydrogen atom, (2) a C1-4 alkyl group or (3) a C1-4 haloalkyl group), (3) -NR23R24 (in the group, R23 and R24 represent, respectively and independently, (1) a hydrogen atom or (2) a C1-4 alkyl group) or (4) an oxo group); R2 represents (1) a hydrogen atom, (2) a C1-4 alkyl group or (3) a C1-4 haloalkyl group; R3 represents (1) a halogen atom, (2) a C1-4 alkyl group, (3) a C1-4 haloalkyl group, (4) a C1-4 alkoxy group, (5) a hydroxy group, (6) -L-CONR6R7, (7) -L-SO2R8 or (8) -L-COOR9; R4 represents (1) a halogen atom, (2) a C1-4 alkyl group or (3) a C1-4 haloalkyl group; L represents (1) a bond, (2) a group represented by the formula: ** Formula ** in which A represents (1) a bond or (2) an oxygen atom; R12 and R13 represent, respectively and independently, (1) a hydrogen atom, (2) a C1-4 alkyl group, (3) a hydroxy group or (4) NH2 or (5) R12 and R13 together with the atom of carbon to which they are attached can form a C3-7 carbocycle; and the arrow on the right side is attached to -CONR6R7, -SO2R8 or -COOR9, (3) a C2-4 alkenylene group, (4) an -O-C2-4 alkenylene group, (5) an oxygen atom, or (6) a nitrogen atom that may be substituted with a C1-4 alkyl group; R6 and R7 represent, respectively and independently, (1) a hydrogen atom, (2) a C1-4 alkyl group, (3) a C1-4 haloalkyl group, (4) a hydroxy group, (5) -CONR15R16, (6) -SO2NR15R16, (7) -COR17 or (8) -SO2R17, or R6 and R7 together with the nit
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