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Derivados de aminopirazol
专利权人:
Chugai Seiyaku Kabushiki Kaisha
发明人:
TAKA, Naoki,OHMORI, Masayuki,TAKAMI, Kyoko,MATSUSHITA, Masayuki,HAYASE, Tadakatsu,HYODO, Ikumi,KOCHI, Masami,NISHII, Hiroki,EBIIKE, Hirosato,NAKANISHI, Yoshito,MIO, Toshiyuki,WANG, Lisha,ZHAO, Weili
申请号:
ES10806527
公开号:
ES2561659T3
申请日:
2010.08.05
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound represented by the following Fomula (I) generally, or a pharmaceutically acceptable salt thereof: Formula ** ** wherein R1, R2, R3, and R4 each independently represents the group listed below: R1 represents hydrogen, hydroxy , halogen, cyano, nitro, C1-4 haloalkyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-10 aryl C1-4 alkyl, -OR5, -NR6R7, - (CR8R9 ) NZ1, -C (O) NR12R13, -SR 14, -SOR15, -SO2R16, - NR17SO2R18, COOH, C6-10 aryl which is optionally substituted by one or more groups independently selected from group P, heteroaryl 5- to 10 members or heterocyclyl 3- to 10-membered is optionally substituted by one or more groups independently selected from group Q, -COR19, -COOR20, - OC (O) R21, -NR22C (O) R23 -NR 24 C (S) R25 , -C (S) NR26R27, -SO2NR28R29, -OSO2R30, -SO3R31, or -Si (R32) 3 R2 represents hydrogen, hydroxy, halogen, cyano, nitro, C1-4 haloalkyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-10 aryl C1-4 alkyl -OR5, - NR6R7, - (CR8R9) NZ1, -C (O) NR12R13, -SR 14, -SOR15, -SO2R16, - NR17SO2R18, COOH, C6-10 aryl which is optionally substituted by one or more groups independently selected from group P, heteroaryl 5- to 10-membered heterocyclyl or 3- to 10-membered which is optionally substituted by one or more groups independently selected from group Q, -COR19, -COOR20, - OC (O) R21, -NR22C (O) R23, -NR 24 C (S) R25, -C (S) NR26R27, -SO2NR28R29, -OSO2R30, -SO3R31, or -Si (R32) 3 or R1 and R2, together with an atom bonded thereto, form a heterocyclyl or 3- to 10-membered heteroaryl 5- to 10 members, wherein the heterocyclyl or heteroaryl is optionally substituted by halogen R3 represents hydrogen, C1-5 alkyl, C6-10 aryl C1-6 alkyl, or C1-4 haloalkyl R4 represents hydrogen, halogen, C1-3 alkyl, C1-3 perfluoroalkyl, cyano, methanesulfonyl, hydroxy, alkoxy, or amino A represents indole or pyrrole R5 represents C1-5 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-3alkoxy C
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