BRODNEY, Michael Aaron,BUTLER, Christopher Ryan,HELAL, Christopher John,O'NEILL, Brian Thomas
申请号：
ES12770239
公开号：
ES2605565T3
申请日:
2012.08.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having the absolute stereochemistry according to formula (I) ** Formula ** in which R1 is hydrogen, C1-6 alkyl, C2-6 alkenyl or - (C (R5aR5b)) m- (C3-6 cycloalkyl)； wherein said alkyl, alkenyl or cycloalkyl moieties may be optionally substituted with one to three R6； R2 is halogen, hydrogen, C1-6 alkyl, C2-6 alkenyl or - (C (R5aR5b)) m- (C3-6 cycloalkyl)； wherein said alkyl, alkenyl or cycloalkyl moieties may be optionally substituted with one to three R6； R3a is hydrogen, C1-6 alkyl, C2-6 alkenyl, - (C (R5aR5b)) m- (C3-6 cycloalkyl), - (C (R5aR5b)) m- (4-10 membered heterocycloalkyl), - (C (R5aR5b )) m- (C6-10 aryl), - (C (R5aR5b)) m- (5-10 membered heteroaryl), - (C (R5aR5b)) m-OR7, - C (O) N (R8) 2, - (C (R5aR5b)) n-NHC (O) R8 or - (C (R5aR5b)) nN (R8) 2； wherein said alkyl, alkenyl, cycloalkyl or heterocycloalkyl moieties may be optionally substituted with one to three R10； and wherein the aryl or heteroaryl moieties independently may be optionally substituted with one to five R10； R3b is hydrogen, C1-3 alkyl, - (C (R5aR5b)) m- (C3-5 cycloalkyl), - (C (R5aR5b)) m- (4-5 membered heterocycloalkyl) or - (C (R5aR5b)) m- OR7； wherein said alkyl, cycloalkyl or heterocycloalkyl moieties may be optionally substituted with one to three R10； R4a and R4e are independently halogen, hydrogen, C1-6 alkyl, -CN or -OR9； wherein said alkyl is optionally substituted with one to three fluoro； R4b and R4d are independently fluoro, chloro, hydrogen, C1-6 alkyl, -CN or -OR12； wherein said alkyl is optionally substituted with one to three fluoro； R4c is halogen, hydrogen, C1-6 alkyl, -CN or -OR12； wherein said alkyl is optionally substituted with one to three fluoro； R5a and R5b are each independently fluoro, hydrogen or C1-6 alkyl； R6 is independently fluoro, -CN, C1-6 alkyl or OR9； R7 is independently hydrogen, C1-6 alkyl, - (C (R5aR5b)) t- (C3-6 cycloalkyl), - (C (R5aR5b)) t- (4-10 membered heterocycloalkyl), - (C (R5aR5b)) t - (C6-10 aryl), - (C (R5aR5b)) t- (5-10 membe
