A compound of the formula (I) ** Formula ** in which R1 is H, OH or NH2； R3 is H, halogen, CN, (C1-C6) alkyl, OH, NH2, or NHR '； R4 is H, halogen, hydroxy, CN, (C1-C6) alkyl, R ', or (C1-C6) -R' alkylene； R5 is H, halogen, CN, (C1-C6) alkyl, or R '； R7 is H, halogen, CN, (C1-C6) alkyl, O-(C1-C6) alkyl, R ', or SO2-NH2； R8 is H, halogen or (C1-C6) alkyl； R9 is OH, halogen, (C1-C6) alkyl, C (O) OH, C (O) NH2, or O-CH3, in which (C1-C6) alkyl is unsubstituted or substituted； R6 is absent or is a (C1-C4) alkylene bonded to the cycloalkyl ring, in which the (C1-C4) alkylene forms a second bond to a carbon atom different from the cycloalkyl ring to form a bicyclic ring system of formula, ** Formula ** or, if mys are 2, m is 3 and s is 1, om is 4 and s is 0, R6 is CH2-CH- (CH2) 2, which is attached with a CH2 to the cycloalkyl ring, and the two other CH2 are attached to carbon atoms different from the cycloalkyl ring； and, if m is 3 and s is 3, R6 are two methylene groups bonded to different carbon atoms of the cycloalkyl ring, in which the methylene groups or the CH2-CH- (CH2) 2 group are attached to the carbon atoms of the cycloalkyl ring so that they form an adamantane system of formula ** Formula ** in which L can be attached to any secondary or tertiary carbon atom, and in which the bicyclic ring system or adamantane system is unsubstituted or optionally substituted with R9； R10 is H, phenyl, O-phenyl, or (C5-C6) heteroaryl, in which phenyl or heteroaryl (C5-C6) is unsubstituted or substituted； R11 is H, (C1-C6) alkyl, (C1-C6) -R 'alkylene, (C3-C8) cycloalkyl, (C5-C10) heteroaryl, (C3-C8) heterocycloalkyl, (C6-C10) aryl； or R11 and R12, together with the carbon atom to which they are attached, form a cycloalkyl (C3-C8) or heterocycloalkyl (C3-C8) ring； R12 is (C1-C6) alkyl, (C3-C8) cycloalkyl, (C5-C10) heteroaryl, (C3-C8) heterocycloalkyl, or (C6-C10) aryl； or R12 is H, with the proviso that r>； = 2 and the other R12 is not H； or R11 and R12, together with the carbo
