ANDERSKEWITZ, RALF,MARTYRES, DOMNIC,OOST, THORSTEN,RIST, WOLFGANG,SEITHER, PETER
申请号：
ES12700695
公开号：
ES2529452T3
申请日:
2012.01.20
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Pyrazole compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof, ** Formula ** in which: Ra and Rb are independently selected from hydrogen, hydroxy, halogen, C1-C6 alkyl, C1-haloalkyl C6, C1-C6 alkoxy, C1-C6 haloalkoxy and C3-C8 cycloalkyl or Ra and Rb together with the carbon atom to which they are attached can form a carbonyl group or Ra and Rb together with the carbon atom to which they are attached to form a 3 to 8 member ring, in which said ring may contain 1 or 2 heteroatoms selected from O, N and S as a member of the ring and in which the ring members of said ring may be optionally independently substituted by hydroxy, halogen , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy and C3-C8 cycloalkyl； Rc and Rd are independently selected from: hydrogen, hydroxy, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy and C3-C8 cycloalkyl or Ra and Rb together with the carbon atom to which they are attached they can form a carbonyl group or Ra and Rb together with the carbon atom to which they are attached to form a 3- to 8-membered ring, in which said ring can contain 1 or 2 heteroatoms selected from O, N and S as ring member and wherein the ring members of said ring may be optionally independently substituted by hydroxy, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy and C3-C8 cycloalkyl； Y1, Y2, Y3, Y4 and Y5 are independently selected from N and CRy, in which each Ry is independently selected from H, hydroxy, halogen, cyano, nitro, SF5, C (O) NRfRg, C1-C6 alkyl, hydroxy -C1-C6 alkyl, [C1-C6 alkoxy] C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 alkoxy-C1-C6 alkoxy, C1-C6 haloalkoxy, C3- cycloalkoxy C8, C1-C6 alkylamino, C1-C6 di-alkylamino, C1-C6 alkylsulfonyl, phenyl, phenoxy, 5 or 6 membered heterocyclyl and 5 or 6 membered heterocyclyloxy, in which Rf and Rg are independently selected from each other of H , C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C3-C8 c
