A compound, or a pharmaceutically acceptable salt thereof, represented by formula IIa: ** (See formula) ** in which "*" indicates a carbon in which the sulfamoyl group may be attached X4 is -NR4- or - OR-； m is 0, 1 or 2； R1 can replace a hydrogen atom of any CH bond in the indole ring and, for each occurrence, is independently deutero, hydroxy, nitro, halo, cyano, carboxy, formyl, C1-7 alkyl, C3-8 carbocyclyl, C2 alkenyl -7, C2-7 alkynyl, C1-7 alkoxy, C1-7 alkylthio, C3-8 cycloalkoxy, C6-10 aryl, C6-10 arylC1-4 C6-10-aryloxy alkyl, amino, N- C1-7 alkylamino, N, N-di- (C1-7 alkyl) amino, N-C6-10 arylamino, 3-10 membered heterocyclyl, N- (3-10 membered heterocyclyl) amino, (3-10 membered heterocyclyl) oxy, 5-10 membered heteroaryl, (5-10 membered heteroaryl) C1-4 alkyl, N-heteroaryl (5-10 membered amino), 5-10 membered heteroaryloxy, C1-7 alkanoyl, C1-7 alkoxycarbonyl, alkanoyloxy C1-7, C1-7 alkylamido, C6-10 arylamido, (3-10 membered heterocyclyl) amido, carbamoyl, N- C1-7 alkyl carbamoyl, N, N-di- (C1-7 alkyl) carbamoyl, C1 alkoxy -7 amido, C1-7 alkyl ureido and C6-10 aryl ureido, in which R1 is optionally substituted in one or more carbon atoms with one or more independently selected R13； and wherein when R1 comprises a heterocyclyl or a heteroaryl comprising one or more - NH-, the hydrogen of each group -NH- can be optionally independently substituted with R22； or two R1 on the same carbon atom together can form an oxo； or two R1 in the same carbon atom together with the carbon to which they are attached form a C3-8 carbocyclyl spiro； or two R1 in adjacent carbon atoms together with the carbon atoms to which they are attached can form a C3-8 condensed carbocyclyl or phenyl which may be optionally substituted with one or more R13； and R3 is selected from the group consisting of a C1-7 alkyl, a C3-8carbocyclyl, a C3-8carbocyclyl C1-4alkyl, a C6-10 aryl, a C6-10arylC1-4alkyl, a 5-10 membered heteroaryl, a (5 to 10 members heteroaryl) C1-4 alkyl, a 3 to 10 member het
