PROBLEM TO BE SOLVED: To provide a highly safe Tie2 activator, an angiogenesis suppressant, an agent for maturating blood vessel, an agent for normalizing blood vessel and an agent for stabilizing blood vessel which respectively has excellent Tie2 activating action, angiogenesis suppressing action, blood vessel maturating action, blood vessel normalizing action, and blood vessel stabilizing action, and a pharmaceutical composition.SOLUTION: The Tie2 activator, angiogenesis suppressant, blood vessel maturating agent, blood vessel normalizing agent and blood vessel stabilizing agent, and pharmaceutical composition includes at least either extract from Quillaja saponaria extract, Engelhardtia chrysolepsis extract, Ginkgo biloba extract, oyster extract, Curcuma longa extract, chrysanthemum morifollum extract, Ziziphus jujuba extract, lycium chinense extract, Matricaria chamomille extract and Ruscus aculeatus extract.【課題】優れたＴｉｅ２活性化作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、及び血管の安定化作用を有する安全性の高いＴｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物の提供。【解決手段】キラヤ抽出物、黄杞抽出物、銀杏抽出物、牡蠣抽出物、ウコン抽出物、菊抽出物、ナツメ抽出物、クコ抽出物、カミツレ抽出物、及びブッチャーブルーム抽出物の少なくともいずれかの抽出物を有効成分として含有するＴｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物である。【選択図】なし
