To provide a highly safe Tie 2 activator, an angiogenesis inhibitor, a blood vessel having a high safety, which has excellent Tie 2 activating action, angiogenesis inhibiting action, blood vessel maturation action, blood vessel normalizing action, and blood vessel stabilizing action A blood vessel normalizing agent, and a blood vessel stabilizing agent, as well as a pharmaceutical composition, a composition for food and drink, and food and drink.SOLUTION: A Tie 2 activator, an angiogenesis inhibitor, a vascular maturation agent, an anti-angiogenesis inhibitor, an anti-angiogenesis inhibitor, an anti-Blood vessel normalizing agent, and blood vessel stabilizing agent, pharmaceutical composition, composition for food and beverage, food and beverage.Selection drawing None【課題】優れたTie2活性化作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、及び血管の安定化作用を有する安全性の高いTie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物、飲食品用組成物、及び飲食品の提供。【解決手段】レンコン抽出物、アシタバ抽出物、サンショウ抽出物、及びヨモギ抽出物の少なくともいずれかの抽出物を有効成分として含有するTie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物、飲食品用組成物、及び飲食品である。【選択図】なし
