PROBLEM TO BE SOLVED: To provide a Tie2 activator, an angiogenesis inhibitor, a blood vessel maturing agent, a blood vessel normalizing agent, a blood vessel stabilizer and a pharmaceutical composition which have excellent Tie2 activating action, angiogenesis inhibitory action, blood vessel maturing action, blood vessel normalizing action and blood vessel stabilizing action and high safety.SOLUTION: A Tie2 activator, an angiogenesis inhibitor, a blood vessel maturing agent, a blood vessel normalizing agent, a blood vessel stabilizer and a pharmaceutical composition include pipernonaline.COPYRIGHT: (C)2014,JPO&INPIT【課題】優れたTie2活性化作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、及び血管の安定化作用を有する安全性の高いTie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤及び血管の安定化剤、並びに医薬品組成物の提供。【解決手段】ピペルノナリンを含有するTie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤及び血管の安定化剤、並びに医薬品組成物である。【選択図】なし
