PROBLEM TO BE SOLVED: To provide a highly safe Tie 2 activator angiogenesis inhibitor, vascular maturation agent, vascular normalizer, and a vascular stabilizer that respectively have excellent Tie 2 activating action, angiogenesis inhibiting action, vascular maturation action, vascular normalizing action, and vascular stabilizing action, and a pharmaceutical composition.SOLUTION: The Tie 2 activator, angiogenesis inhibitor, vascular maturation agent, vascular normalizer, and vascular stabilizer contain at least one selected from a linden extract and a horse chestnut extract as an active ingredient and the pharmaceutical composition contains at least any one of these.SELECTED DRAWING: None
