PROBLEM TO BE SOLVED: To provide a Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an anti-angiogenic agent, an agent for maturing blood vessels, an agent for normalizing blood vessels and an agent for stabilizing blood vessels, which are highly safe and respectively have superior Tie2 activating effect, vascular endothelial growth factor (VEGF) inhibitory effect, anti-angiogenic effect, blood vessel maturing effect, blood vessel normalizing effect and blood vessel stabilizing effect and to provide a pharmaceutical composition.SOLUTION: The Tie2 activator, the vascular endothelial growth factor (VEGF) inhibitor, the anti-angiogenic agent, the agent for maturing blood vessels, the agent for normalizing blood vessels and the agent for stabilizing blood vessels each containing an extract of hawthorn as an active ingredient, and the pharmaceutical composition are provided.COPYRIGHT: (C)2012,JPO&INPIT【課題】優れたTie2活性化作用、血管内皮増殖因子(VEGF)阻害作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、及び血管の安定化作用を有する安全性の高いTie2活性化剤、血管内皮増殖因子(VEGF)阻害剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物の提供。【解決手段】サンザシの抽出物を有効成分として含有するTie2活性化剤、血管内皮増殖因子(VEGF)阻害剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物である。【選択図】図1
