PROBLEM TO BE SOLVED: To provide a highly safe Tie2 activator, an angiogenesis suppressant, an agent for maturating blood vessel, an agent for normalizing blood vessel and an agent for stabilizing blood vessel which respectively has excellent Tie2 activating action, angiogenesis suppressing action, blood vessel maturating action, blood vessel normalizing action, and blood vessel stabilizing action, and a pharmaceutical composition.SOLUTION: The Tie2 activator, angiogenesis suppressant, blood vessel maturating agent, blood vessel normalizing agent and blood vessel stabilizing agent, and pharmaceutical composition includes at least either extract from Averrhoa carambola extract, Alpinia speciosa extract, Nelumbo nucifera extract, aspalathus linearis extract, Tamarindus indica extract, Chaenomeles sinensis extract, Psidium guajava extract, and Piper longum extract, as an effective ingredient.【課題】優れたＴｉｅ２活性化作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、及び血管の安定化作用を有する安全性の高いＴｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物の提供。【解決手段】スターフルーツ抽出物、ゲットウ抽出物、ハス抽出物、ルイボス抽出物、インディアンデーツ抽出物、カリン抽出物、シジュウムグァバ抽出物、及びヒハツ抽出物の少なくともいずれかの抽出物を有効成分として含有するＴｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物である。【選択図】なし
