PROBLEM TO BE SOLVED: To provide a peptide having an abnormality blood vessel relaxation effect for blood vessels, and a blood vessel relaxation agent and blood flow improving agent comprising such a peptide as an active ingredient.SOLUTION: The present invention relates to a peptide having in a molecule an amino acid sequence Pro-Gly-Gly (Pro-Gly-Gly-Val or Pro-Gly-Gly-Val-Gly), and a blood vessel relaxation agent and blood flow improving agent comprising any one peptide of Pro-Gly-Gly, Pro-Gly-Gly-Val or Pro-Gly-Gly-Val-Gly as an active ingredient.COPYRIGHT: (C)2015,JPO&INPIT【課題】血管の異常血管弛緩作用を有するペプチドや、かかるペプチドを有効成分とする血管弛緩剤並びに血流改善剤の提供。【解決手段】分子内にアミノ酸配列Pro-Gly-Glyを有するペプチド(Pro-Gly-Gly-Val又はPro-Gly-Gly-Val-Gly)や、Pro-Gly-Gly、Pro-Gly-Gly-Val又はPro-Gly-Gly-Val-Glyのいずれかのペプチドを有効成分とする血管弛緩剤や血流改善剤。【選択図】なし