PROBLEM TO BE SOLVED: To provide a Tie2 activator, an angiogenesis inhibitor, a blood vessel maturing agent, a blood vessel normalizing agent, a blood vessel stabilizer and a pharmaceutical composition which have excellent Tie2 activating action, angiogenesis inhibitory action, blood vessel maturing action, blood vessel normalizing action and blood vessel stabilizing action and high safety.SOLUTION: A Tie2 activator, an angiogenesis inhibitor, a blood vessel maturing agent, a blood vessel normalizing agent, a blood vessel stabilizer and a pharmaceutical composition include an extract of Astragalus complanatus as an active ingredient.