PROBLEM TO BE SOLVED: To provide a highly safe Tie2 activator, an angiogenesis suppressant, an agent for maturating blood vessel, an agent for normalizing blood vessel and an agent for stabilizing blood vessel which respectively has excellent Tie2 activating action, angiogenesis suppressing action, blood vessel maturating action, blood vessel normalizing action, and blood vessel stabilizing action, and a pharmaceutical composition.SOLUTION: The Tie2 activator, angiogenesis suppressant, blood vessel maturating agent, blood vessel normalizing agent and blood vessel stabilizing agent, and pharmaceutical composition includes at least either extract from Averrhoa carambola extract, Alpinia speciosa extract, Nelumbo nucifera extract, aspalathus linearis extract, Tamarindus indica extract, Chaenomeles sinensis extract, Psidium guajava extract, and Piper longum extract, as an effective ingredient.
