Tie2 ACTIVATOR, NEOVASCULARIZATION INHIBITOR, BLOOD VESSEL MATURING AGENT, BLOOD VESSEL NORMALIZING AGENT, AND BLOOD VESSEL STABILIZER, AS WELL AS PHARMACEUTICAL COMPOSITIONS AND FOOD AND DRINKS
PROBLEM TO BE SOLVED: To provide a Tie2 activator, neovascularization inhibitor, blood vessel maturing agent, blood vessel normalizing agent, and blood vessel stabilizer, as well as pharmaceutical compositions and food and drinks having high safety and excellent effects of Tie2 activation, angiogenesis inhibition, blood vessel maturation, blood vessel normalization, and blood vessel stabilization.SOLUTION: The invention provides a Tie2 activator, neovascularization inhibitor, blood vessel maturing agent, blood vessel normalizing agent, and blood vessel stabilizer, as well as pharmaceutical compositions and food and drinks containing at least any of Piper longum extract, Aspalathus linearis extract, and Alpinia zerumbet extract as an active ingredient.SELECTED DRAWING: None【課題】優れたTie2活性化作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、及び血管の安定化作用を有する安全性の高いTie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物、及び飲食品の提供。【解決手段】ヒハツ抽出物、ルイボス抽出物、及びゲットウ抽出物の少なくともいずれかの抽出物を有効成分として含有するTie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物、及び飲食品である。【選択図】なし