HUCK, Bayard R.,NEAGU, Constantin,JONES, Reinaldo C.,DESELM, Lizbeth Celeste,XIAO, Yufang,KARRA, Srinivasa R.,LAN, Ruoxi,MOCHALKIN, Igor,SUTTON, Amanda E.,RICHARDSON, Thomas E.
申请号：
ES11738160
公开号：
ES2557383T3
申请日:
2011.07.01
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of formula (I) ** Formula ** and its salts, solvates or solvates of pharmaceutically acceptable salts, wherein X is N or C-R3, Y is NH, O or is absent, R1 is L1-R4-L2- R5 or L1-R4, R2 is A, Hal, OH, OA, SH, CN, NH2, NO2, NHA, NH-L1-Ar, NHCOA, NHCO-L1-Ar, NHSO2A, NHSO2-L1-Ar, NHCONHA, NHCONH-L1-Ar, L1-Ar, O-L1-Ar, L1-R4, L1 is a single bond, methylene or methyl substituted methylene, where methylene or the methyl group of methyl substituted methylene may not be substituted or it may be mono- or disubstituted with Hal, OH, CN, NH2, NH (LA), N (LA) 2, NO2, COOH, N3, ethenyl or ethynyl, and / or monosubstituted with R4 and wherein one or two groups CH2 can be replaced by an O or S atom or by a group -NH-, -N (LA) -, -CONH-, -N (LA) COO-, -SO2- or -NHCO-, R3 is H , A, Hal, OH, COOH, SH, NH2, NO2 or CN, R4, R5 are each, independently of each other, Ar or Cyclic A which may be mono- or disubstituted with Hal or LA, L2 is -NHCO -, -NHCOO-, -NHCONH-, -NHCONA-, -NHCOA- , -O-, -S-, -NH-, -NHSO2-, -SO2NH-, -CONH-, -CONHCONH-, -NHCONHCO- or -A-, Ar is a mono- or bicyclic aromatic homo- or heterocycle that it has 0, 1, 2, 3 or 4 atoms of N, O and / or S and 5, 6, 7, 8, 9 or 10 atoms of the skeleton, which may not be substituted or, independently of each other, may be mono-, di- or trisubstituted with Hal, A, OH, SH, OA, NH2, NHA, NA2, NO2, CN, OCN, SCN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHCONHA, NHCONH2, NHSO2A, CHO, COA, SO2NH2, SO2A and / or SO2Hal, and where an N atom of the ring can be substituted with an O atom to form a Noxyl group, and where in the case of a bicyclic aromatic cycle in two of the rings may be partially saturated, A is a non-branched or branched linear or cyclic alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 C atoms, where one or two CH2 groups may be replaced by a O or S atom and / or by a group -NH-, -CO-, -NHCOO-, -NHCONH-, -N (LA) -, -CONH-, -NHCO- or -CH>； = CH- and where 1-3 H atoms can be replaced by Hal and where one or two CH3 groups can be
