TSAKLAKIDIS, Christos,STAEHLE, Wolfgang,LEUTHNER, Birgitta,FUCHSS, Thomas
申请号：
ES14739685
公开号：
ES2633969T3
申请日:
2014.07.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compounds of formula I ** (See formula) ** in which R denotes Ar or Het, Y denotes -CO-W or -N (R4) CO-W1, W denotes NR2R2 ', Het1, CH2Het1, A, Cyc , Ar or CH2Ar, -CONR2R2 'or Het1, W1 denotes NR2R2', Het1, CH2Het1, A, Cyc, Ar, CH2Ar, CH2Cyc or CH (OH) CH2OH, R1 denotes H, F, Cl, Br, OH, CN, NO2, A ', OA', SA ', SO2Me, COA', CONH2, CONHA 'or CONA'2, R2, R2' each, independently of each other, denote H, A or [C (R3) 2] nCyc , X1, X2, X3 each, independently of each other, denotes CR8 or N, X4 denotes CR8 or N, X5 denotes CR8 or N, R4 denotes H or A ', A denotes unbranched or branched alkyl with 1-10 atoms of C, in which two adjacent C atoms can form a double bond and / or one or two non-adjacent CH and / or CH2 groups can be substituted by N-, O- and / or S atoms and where 1-7 H atoms can be replaced by R5, Cyc denotes cycloalkyl with 3-7 C atoms, which is unsubstituted or monosubstituted by OH, Hal or A, A 'denotes unbranched or branched alkyl with 1-6 C atoms, wherein 1-5 H atoms can be replaced by F, R5 denotes F, Cl or OH, Ar denotes phenyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentas substituted by Hal, A, O [C (R3) 2] nHet1, Ar1, [C (R3) 2] pOR3, [C (R3) 2] pN (R3) 2, NO2, CN, [C (R3) 2] pCOOR3, CON (R3 ) 2, Het1, OCH2Cyc, [C (R3) 2] pN (R3) 2, N (R3) 2COA, NR3SO2A, [C (R3) 2] pSO2N (R3) 2, S (O) nA, O [C (R3) 2] mN (R3) 2, NHCOOA, NHCON (R3) 2 and / or COA, Ar1 denotes phenyl or naphthyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentas substituted by Hal, A, [C (R3) 2] pOR3, [C (R3) 2] pN (R3) 2, NO2, CN, C (R3) 2] pCOOR3, [C (R3) 2] pN (R3) 2, N (R3) 2COA, NR3SO2A, [C (R3) 2] pSO2N (R3) 2, S (O) nA, O [C (R3) 2] mN (R3) 2, NHCOOA, NHCON (R3) 2 and / or COA, R3 denotes H or unbranched or branched alkyl with 1-6 C atoms, R8 denotes H or A ', Het denotes a saturated, unsaturated or aromatic mono- or bicyclic heterocycle having 1 to 4 atoms of N, O and / or S, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Ha
