TSAKLAKIDIS, Christos,STAEHLE, Wolfgang,LEUTHNER, Brigitta,CZODROWSKI, Paul
申请号：
ES13779143
公开号：
ES2608355T3
申请日:
2013.10.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compounds of formula I ** Formula ** in which R indicates Ar, Het, -C≡C-Ar or -C≡C-Het, W indicates NR2R2 'or Het1, R1 indicates A, [C (R3) 2] nAr1 or [C (R3) 2] nCyc, R2, R2 'each, independently of each other, indicate H, A or [C (R3) 2] nCyc, R4 indicates H, F, Cl, a, OH, CN, NO2, A ', OA', SA ', SO2Me, COA', CONH2, CONHA 'or CONA'2, X1, X2, X3, X4 each, independently of each other, indicate CH or N, A indicates unbranched alkyl or branched with 1-10 C atoms, in which two adjacent carbon atoms can form a double bond and / or one or two non-adjacent groups of CH- and / or CH2, can be replaced with N-, O- and / or S-atoms and in which 1-7 H atoms can be replaced with R5, Cyc indicates cycloalkyl with 3-7 C atoms, being unsubstituted or monosubstituted with OH, Hal or A, A 'indicates unbranched or branched alkyl with 1-6 C atoms, in which 1-5 H atoms can be replaced with F, R5 indicates F, Cl or OH, Ar indicates phenyl, being unsubstituted or mono-, di-, tri-, tetra- or pe ntasubstituted with Hal, A, O [C (R3) 2] nHet1, Ar1, [C (R3) 2] pOR3, [C (R3) 2] pN (R3) 2, NO2, CN, [C (R3) 2 ] pCOOR3, CON (R3) 2, [C (R3) 2] pN (R3) 2, N (R3) 2COA, NR3SO2A, [C (R3) 2] pSO2N (R3) 2, S (O) nA, O [C (R3) 2] mN (R3) 2, NHCOOA, NHCON (R3) 2 and / or COA, Ar1 indicates phenyl or naphthyl, being unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted with Hal , A, [C (R3) 2] pOR3, [C (R3) 2] pN (R3) 2, NO2, CN, [C (R3) 2] pCOOR3, [C (R3) 2] pN (R3) 2 , N (R3) 2COA, NR3SO2A, [C (R3) 2] pSO2N (R3) 2, S (O) nA, O [C (R3) 2] mN (R3) 2, NHCOOA, NHCON (R3) 2 and / or COA, R3 indicates H or unbranched or branched alkyl with 1-6 C atoms, Het indicates a saturated, unsaturated or aromatic mono- or bicyclic heterocycle having 1 to 4 atoms of N, O and / or S , being unsubstituted or mono-, di-, tri-, tetra- or pentas substituted with Hal, A, [C (R3) 2] nOA ', [C (R3) 2] nN (R3) 2, SR3, NO2, CN, COOR3, CON (R3) 2, COHet1, NR3COA, NR3SO2A, SO2N (R3) 2, S (O) nA, O [C (R3) 2] mN (R3) 2, NHCOO
