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Thiazole derivatives for the treatment of diseases, such as cancer
专利权人:
MERCK PATENT GMBH
发明人:
HEINRICH, TIMO,KOOLMAN, HANNES
申请号:
ES10779706
公开号:
ES2543742T3
申请日:
2010.11.09
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compounds of the formula ** Formula ** wherein R1 represents H, (CH2) nAr or (CH2) nHet, R1 'represents H or A, R2 represents H, A, Hal, (CH2) nHet1, (CH2) nHet3, -C≡C-Ar, (CH2) nAr2, NHCONHAr, COA, COOH, COOA, COHet1, COAr2, CONH2, CONHA, CONA2, SO2NH2, SO2NHA, S (O) mA, NHCOA, SO2NHA, SO2NA2, SO2NHH2, SO2NHAr2, SO2NHAr2 R7 represents H, A, Ar or Het1, Ar represents unsubstituted or mono-, di-, or tri- substituted phenyl by Hal, A, OH, OA, CN, NO2, SO2A, COOH, COOA, NH2, NHA, NA2 , NHCH2Ar1, CHO, COA, CHO, CONH2, CONHA, CONA2, Het, SO2NH2, SO2NHA, S (O) mA and / or NHCOA, Het represents a mononuclear or binuclear aromatic heterocycle with 1 to 4 atoms of N, O and / or of S, which is unsubstituted or may be mono-, di- or tri-substituted by Hal, A, NH2, NHA, NA2, COOH, COOA, CONH2, CONHA, CONA2, CONHAr, CONHHet4, S (O) mA and / or NHCH2Ar1, Ar1 represents unsubstituted or mono-, di- or tri- substituted phenyl by Hal, A, OH and / or OA, Ar2 represents phenyl mono-substituted by NHCONHHet4, Het1 represents a mon heterocycle o- or bi-nuclear saturated, unsaturated or aromatic with 1 to 4 atoms of N, O and / or S, which is unsubstituted or can be mono-, di- or tri-substituted by Hal, A, COOA, NH2, NHR8 and / or (CH2) nHet2, R8 represents H, A, Ar1 or Het4, R9, R10, respectively independently of each other, represent H or Hal, R11 represents H or A ', Het2 represents a heterocycle mononuclear or binuclear aromatic with 1 to 4 atoms of N, O and / or S, which can be mono-, di- or tri-substituted by A, COOA and / or by NH2, Het3 represents a mononuclear or binuclear aromatic heterocycle with 1 to 4 atoms of N, O and / or S, which can be mono-, di- or tri-substituted by NH2, Het4 represents a saturated, unsaturated or aromatic mono- or bi-nuclear heterocycle with 1 to 4 atoms of N, O and / or S, which is unsubstituted or may be mono-, di- or tri-substituted by Hal, A, Ar1, NH2, NHCH2Ar1 and / or>; = O, A represents unbranched alkyl or branched with 1-10 atoms of C, where 1-
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