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Tricyclic derivatives of Pirazol Amina
专利权人:
Merck Serono S.A.
发明人:
GAILLARD, Pascale,JEANCLAUDE-ETTER, Isabelle,POMEL, Vincent,SEBILLE, Eric,JEYAPRAKASHNARAYANAN, Seenisamy,MUZERELLE, Mathilde
申请号:
ES10775841
公开号:
ES2607952T3
申请日:
2010.11.12
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I *): ** Formula ** where X1 denotes a nitrogen atom or CR3, X2, X5 are independently of each other nitrogen or carbon atoms, U denotes a 6-atom aromatic ring optionally having 1, 2 or 3 nitrogen atoms, including X5, or a 5-atom aromatic or unsaturated ring having 1 to 3 heteroatoms selected from N, S, or O, including the meaning of X5, Z denotes an aromatic or unsaturated heterocyclic ring of 5 atoms with 2 nitrogen atoms, including the meaning of X2. T indicates S, SO or SO2, R1 indicates H, A, Hal, CN, NO2, N (R6) 2, OR6, Ar, Het, Y, -NR6COR6, CON (R6) 2, -NR6COAr, NR6COHet, COHet, -NR6SO2R6, CO2R6, including CO2Y, R2 indicates H, Ar, Het, A, Cic, R3 indicates H, Y, R4 indicates H, Y, (CH2) nAr, (CH2) nCic, (CH2) nHet, (CH2) nOY, (CH2) nNHY, (CH2) nNH2 or if X1 is CR3, also Hal, R5 indicates H, Y, or Ar, when R5 is Y and r is 2, two R5 groups can be linked together to provide with the morpholine group to which they are attached, a bridge system. R6 is H, A, Cic or Ar. u is 0, 1, 2, 3 or 4, r is 0, 1 or 2, g is 1 or 2, Ar denotes a fused unsaturated or aromatic, monocyclic or bicyclic carbocyclic ring having 6 to 14 non-carbon atoms is substituted or monosubstituted, disubstituted or trisubstituted by Hal, OCF3, NO2, CN, perfluoroalkyl, A, OR6, N (R6) 2, COR6, -CO2R6, CON (R6) 2, COHet, -NHCOR6, -NHSO2A, - NHSO2Ar, -NHSO2- N (R6) 2, N (H) 1-qAqCOR6, N (H) 1-qAqSO2-N (H) 2-m (A) m, -N (H) 1-qAqCON (H) 2-m (A) m, -SO2A, -SO2Ar, -SO2N (H) 2-m (A) m, -SO2Het, - (CH2) nN (R6) 2, - (CH2) n-OR6, - ( CH2) nN (R6) SO2A, - (CH2) nN (R6) SO2R6, Het2, - (CH2) n-Het2, - (CHY) n-Het2; Het indicates a saturated, unsaturated or aromatic, monocyclic or bicyclic heterocyclic ring having 1, 2, 3 or 4 atoms of N, O and / or S and finally contains a group SO2 or CO that is unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, OCF3, NO2, CN, perfluoroalkyl, A, OR6, N (R6) 2, COR6, -CO2R6, CON (R6) 2, - NHCOR6, -NHSO2A, -NHSO2R6, -NHSO2-N (H) 2
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