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7-Azaindole derivatives
专利权人:
Merck Patent GmbH
发明人:
DORSCH, Dieter,SIRRENBERG, Christian,MUELLER, Thomas,MERKUL, Eugen,KARAPETYAN, Gnuni Amatunu
申请号:
ES12701437
公开号:
ES2608317T3
申请日:
2012.01.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of the formula I ** Formula ** in which R represents 2,6-naphthyridin-1- or -4-yl unsubstituted or substituted once or twice with R5, R1 represents H or A ', R2 represents H, A 'or - [C (R6) 2] n-Ar, R3 represents H, A, Hal, CN, - [C (R6) 2] n-Ar, - [C (R6) 2] n-Het, - [C (R6) 2] n-Cyc, OR6 or N (R6) 2, R5 represents A, Hal, CN, - [C (R6) 2] n-Ar, - [C (R6) 2] n-Het , - [C (R6) 2] n-Cyc, OCyc, OHet ', OR6, N (R6) 2, SO2A, SO2Ar or>; = O, R6 represents H or A', A represents a linear or branched alkyl of 1 -6 atoms of C in which one or two groups CH2 can be substituted by atoms of O, N and / or S and / or by groups -CH>; = CH and / or also 1-7 atoms of H by F, A 'represents a linear or branched alkyl of 1-4 C or Cyc atoms, Cyc represents a cycloalkyl of 3, 4, 5, 6 or 7 C atoms, Ar represents an unsubstituted or substituted phenyl once, twice or three times with Hal, A, [C (R6) 2] nOR6, N (R6) 2, NO2, CN, COOR6, CON (R6) 2, NR6COA, NR6SO2A, COR6, SO2N (R6) 2 and / or S (O) nA , Het represents a heterocycle of one or two rings saturated, unsaturated or aromatic with 1 to 4 atoms of N, O and / or S not substituted or substituted once or twice with Hal, A, [C (R6) 2] nOR6, N (R6) 2, NO2, CN, COOR6, CON (R6) 2, NR6COA, NR6SO2A, COR6, SO2NR6 and / or S (O) nA, Het 'represents a saturated ring heterocycle with 1 or 2 atoms of N, O, and / or S unsubstituted or once or twice substituted with A and / or>; = O, Hal represents F, Cl, Br or I, N represents 0, 1 or 2, as well as its salts, tautomers and stereoisomers for pharmaceutical use, including mixtures thereof in all proportionsCompuestos de la fórmula I**Fórmula** en los que R representa 2,6-naftiridin-1- o -4-ilo no sustituido o sustituido una o dos veces con R5, R1 representa H o A', R2 representa H, A' o -[C(R6)2]n-Ar, R3 representa H, A, Hal, CN, -[C(R6)2]n-Ar, -[C(R6)2]n-Het, -[C(R6)2]n-Cyc, OR6 o N(R6)2, R5 representa A, Hal, CN, -[C(R6)2]n-Ar, -[C(R6)2]n-Het, -[C(R6)2]n-Cyc, OCyc, OHet', OR6, N(R6)2,
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