MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
DR. DIPL.-CHEM. DORSCH DIETER,DR. SIRRENBERG CHRISTIAN,PROF. DR. MUELLER THOMAS J. J.,DIPL.-CHEM. MERKUL EUGEN,KARAPETYAN GNUNI
申请号：
ARP120100332
公开号：
AR085110A1
申请日:
2012.02.01
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
They are inhibitors of PDK1 and Cell Proliferation / cell Vitality and can be used in the treatment of tumors.Claim 1: compounds of the formula (1), where r is indazol - 3 -, 4 - or - 7 - ILO, imidazo [1,2-a] - pyrimidine - 3 - or 5 - ILO, cinolin - 4 -, 5 -, 8 - or - - ILO, isoquinolin - 1 - - 4 -, 5 - or 6 - ILO, 1h pyrrolo [c] pyridin - 3.2 - 3 -, 4 - or - 7 - ILO, 1h pyrrolo [2,3-c] pyridin - 3 -, 4 - or - 7 - ILO, furo [2,3-c] pyridin-3 - 3 - - 4 - - 7 - or ILO, furo [3,2-b] pyridin - 3 - or - 7 - ILO, naftiridin 2.6 - - 1 - - 4 or - 2.7 - 4 - naftiridin ILO, ILO, pirido [23 - B] pirazin - 7 - 8 - i or - or mono - or non substituted chinolin disubstituted with R5； amino - 4 -, 5 - or - 8 - ilo； naftiridin - 1.8 - 1.8 - or 4 - Ilo Ilo naftiridin - 4 - substituted or not monosustituido in position 7 with R5, which can be substituted in position 2 with Hal, CN, - [C (r6) 2] n - CYC, or6 (r6), n 2, SO2 or So2ar； r1 is H OR； R2 is H, o - [C (r6) 2] n ar； R3 is H, a, Hal, CN, - [C (r6) 2] n - AR, - [C (r6) 2] n - Het,- [C (r6) 2] n - or n or6 CYC (r6)； 2 is to R5, Hal, CN, - [C (r6) 2] n - AR, - [C (r6) 2] n - Het, - [C (r6) 2] n - CYC. Ocyc, ohet, or6 (r6), n 2, SO2, so2ar or R6 u = h； or； is unbranched or branched alkyl with 1 to 6 c ATOMS, where one or two CH2 groups can be replaced by Atoms or,N / s and / or groups - ch = CH - and / or 1 - 7 h Atoms can be replaced by F； is unbranched or branched alkyl with 1 to 4 c Atoms or CYC CYC is cycloalkyl； 3, 4, 5, 6 or 7 c Atoms ar is phenyl or substituted； not mono -, Di - or trisustituido with Hal,, - C (r6) [2] nor6 (r6), n 2, NO2, CN, coor6 (r6), with 2, nr6coa, nr6so2a, cor6,So2n (r6) 2 and / or s (or na)； Het is a mono - or bicyclic heterocycle Aromatic unsaturated or saturated, not replaced or mono - or alkylated with Hal,, C - [2] nor6 (r6), N (r6) 2, NO2, CN, coor6, (R6 2), nr6coa, nr6so2a, cor6, so2nr6 and / or s (or na) with 1 to 4 Atoms of N or s, and / or heterocycle； Het is a monoc u00edc LICO satura
