MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
TSAKLAKIDIS, CHRISTOS,DORSCH, DIETER,MEDERSKI, WERNER,CEZANNE, BERTRAM,GLEITZ, JOHANNES
申请号：
CA2521069
公开号：
CA2521069C
申请日:
2004.03.08
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention relates to the compounds of formula (I), wherein W represents N,CR3, or a sp2hybridized C atom, E, together with W, represents a 3- to 7-membered saturatedcarbocylic orheterocyclic ring having 0 to 3 N atoms, 0 to 2 O atoms and/or 0 to 2 S atoms,which ring maycontain a double bond, D represents a mononuclear or binuclear unsubstitutedaromaticcarbocycle or heterocycle having 0 to 4 N atoms, O atoms and/or S atoms orbeingmonosubstituted or polysubstituted by Hal, A, OR3, N(R3)2, NO2, CN, COOR3 orCON(R3)2,G represents -[C(R4)2]n-, -[C(R4)2]nNR3-, -[C(R4)2]nO-, -[C(R4)2]nS- or -[C(R4)=C(R4)]n-,X represents -[C(R4)2]nCONR3[C(R4)2]n-, -[C(R4)2]nNR3CO[C(R4)2]n-, -[C(R4)2]nNR3[C(R4)2]n-, -[C(R4)2]nO[C(R4)2]n-, -[C(R4)2]nCO[C(R4)2]n- or -[C(R4)2]nCOO[C(R4)2]n-, Y represents alkylene, cycloalkylene, Het-diyl or Ar-diyl, Trepresents a mononuclear or binuclear saturated or unsaturated carbocycle orheterocycle having0 to 4 N atoms, O atoms and/or S atoms, which is monosubstituted orpolysubstituted by =O, =S,=NR3, =N-CN, =N-NO2, =NOR3, =NCOR3, =NCOOR3, =NOCOR3 and which may further bemonosubstituted, disubstituted or trisubstituted by R3, Hal, A,-[C(R4)2]n, -Ar, -[C(R4)2]n-het, -[C(R4)2]n-cycloalkyl, OR3, N(R3)2, NO2, CN, COOR3, CON(R3)2, NR3COA,NR3CON(R3)2, NR3SO2A, COR3, SO2NR3 and/or S(O)nA, and R1 and R2 are defined asinclaim 1. The inventive compounds inhibit coagulation factor Xa and can be usedin theprophylaxis and/or therapy of thrombo-embolic diseases and for treatingtumors.
