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Bipyridyl derivatives useful for the treatment of kinase-induced diseases
专利权人:
MERCK PATENT GMBH
发明人:
HOELZEMANN, GUENTER,DORSCH, DIETER,JONCZYK, ALFRED,ZENKE, FRANK,AMENDT, CHRISTIANE
申请号:
ES11724136
公开号:
ES2535656T3
申请日:
2011.06.07
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound of formula (I) ** Formula ** where: W1, W2, W3 indicate CR3, or W1, W2 indicate CR3, and W3 indicate N, R1 indicates phenyl, which may be independently substituted by at least one substituent selected from from the group consisting of Y, Hal, CN, CF3 or OY, R2 indicates Ar, Het1, Het2, NY-Het1 or NY-Het2, each of which may be independently substituted from each other by R4, R3 indicates H, R4 indicates Hal, A, - (CYY) n-OY, - (CYY) n-NYY, (CYY) n-Het³, (CYY) nO-Het³, SY, NO2, CF3, CN, COOY, - CO-NYY, - NY-COA, -NY-SO2A, -SO2-NYY, S (O) mA, -CO-Het³, -O (CYY) n-NYY, -O (CYY) n-Het³, -NHCOOA, -NH-CO -NYY, -NH-COO- (CYY) n-NYY, -NH-COO- (CYY) n-Het³, -NH-CO-NH- (CYY) n-NYY, -NHCO- NH (CYY) n- Het³, -OCO-NH- (CYY) n-NYY, -OCO-NH- (CYY) n-Het³, CHO, COA,>; = S,>; = NY and>; = O, Y indicates H or A, A indicates a branched or unbranched alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, in which 1, 2, 3, 4, 5, 6 or 7 H atoms they can be independently substituted for each other by Hal and / or in where one or two CH2 groups can be independently substituted for each other by O, S, SO, SO2, a group -CY>; = CY- and / or a group -C ° C-, Ar indicates a saturated, unsaturated monocyclic or bicyclic carbocycle aromatic having 5, 6, 7, 8, 9 or 10 C atoms, Het1 indicates a saturated, unsaturated mono, bi or tricyclic heterocycle having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 atoms of C and 1, 2, 3, 4 or 5 atoms of N, O and / or S, Het2 indicates a mono, bi or tricyclic heteroaryl that it has 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 atoms of C and 1, 2, 3, 4 or 5 atoms of N, O and / or S, Het3 indicates a saturated, unsaturated mono, bi or tricyclic heterocycle having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 , 17, 18, 19 or 20 atoms of C and 1, 2, 3, 4 or 5 atoms of N, O and / or S, which may be independently substituted from each other by at least one substituent selected from the Hal group , A, - (CYY) n
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