DORSCH, DIETER,SCHADT, OLIVER,BLAUKAT, ANDREE,STIEBER, FRANK
申请号：
CA2660195
公开号：
CA2660195C
申请日:
2007.07.12
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Compounds of formula I(see formula I)in which R1 denotes Ar or Het, R2 denotes a saturated, unsaturated or aromatic5-membered heterocycle having 1 to 4 N, O and/or S atoms, which may beunsubstituted or mono- or disubstituted, R3 denotes H or A, R4 and R5 eachdenoteH, Hal, A, OR3, CN, COOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2 or S(O)m A,A denotes C1-10 alkyl, in which 1-7 H atoms may be replaced by F, CI and/orBr,and/or in which one or two CH2 groups may be replaced by O, S, SO, SO2 and/orCH=CH groups, or C3-7 cyclic alkyl, Ar denotes phenyl, naphthyl or biphenyl,each ofwhich is unsubstituted or mono-, di- or trisubstituted, Het denotes a mono-,bi- ortricyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, Oand/or Satoms, which may be unsubstituted or mono-, di- or trisubstituted, Hal denotesF, CI,Br or I, m denotes 0, 1 or 2, or a pharmaceutically usable solvate, salt,tautomer orstereoisomer thereof, or a mixture thereof in any ratio, are inhibitors oftyrosinekinases and can be employed inter alia for the treatment of tumours.
