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Bicyclic triazole derivatives for the treatment of tumors
专利权人:
Merck Patent GmbH
发明人:
STIEBER, Frank,SCHADT, Oliver,DORSCH, Dieter,BLAUKAT, Andree
申请号:
ES09777234
公开号:
ES2648233T3
申请日:
2009.07.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of the formula I ** Formula ** where X1, X2, X3, X4, X5 independently represent in each case CH or N, R1 represents H, Hal, A, S (O) mA, Ar, Het, O [C (R5) 2] nAr, O [C (R5) 2] nHet or OR5, R7 represents H or Hal, R2 represents A, Hal, [C (R5) 2] nN (R5) 2, [C (R5 ) 2] nHet, O [C (R5) 2] pN (R5) 2, O [C (R5) 2] nHet, [C (R5) 2] nOR5, O [C (R5) 2] OR5, O- [C (R5) 2] n-cycloalkylene- [C (R5) 2] nN (R5) 2, [C (R5) 2] nNR5COOA or CH>; = CH-COOR5, R3, R3 'independently represent each case H or R8, R4, R6 represent H, R5 represents H or R8, R8 represents unbranched or branched alkyl with 1-6 C atoms, A represents unbranched or branched alkyl with 1-10 C atoms, where 1- 7 H atoms can be replaced by OH, F, Cl and / or Br, or cyclic alkyl with 3-7 C atoms, which may be substituted once with OH, Ar represents unsubstituted or substituted phenyl once, twice or three times with Hal, A and / or CN, Het represents piperidinyl, pyrrolidinyl, morpholinyl, piperazinyl, oxazolidinyl, pyrazolyl, p iridinyl, pyrimidinyl, furyl, thienyl, oxazolyl, oxadiazolyl, imidazolyl, pyrrolyl, isoxazolyl or imidazolidinyl, where these groups may also be substituted once or twice with Hal, A, COOR5, O [C (R5) 2] pOR5, [C (R5) 2] nHet1, O [C (R5) 2] nHet1 and / or>; = O, Het1 represents piperidinyl, pyrrolidinyl, morpholinyl, piperazinyl, oxazolidinyl or imidazolidinyl, where these groups can also be substituted once or twice with COOA ,>; = O and / or A, Hal represents F, Cl, Br or I, m represents 0, 1 or 2, n represents 0, 1, 2, 3 or 4, p represents 1, 2, 3 or 4 and also its pharmaceutically acceptable salts, tautomers and stereoisomers, including mixtures in all proportions.Compuestos de la fórmula I**Fórmula** donde X1, X2, X3, X4, X5 representan en forma independiente en cada caso CH o N, R1 representa H, Hal, A, S(O)mA, Ar, Het, O[C(R5)2]nAr, O[C(R5)2]nHet o OR5, R7 representa H o Hal, R2 representa A, Hal, [C(R5)2]nN(R5)2, [C(R5)2]nHet, O[C(R5)2]pN(R5)2, O[C(R5)2]nHet, [C(R5)2]
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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