The present invention relates to a manufacturing method of Luffa cylindrica juice with enhanced nutritious components and more specifically, the invention comprises: a Luffa cylindrica washing step for washing the Luffa cylindrica a grinding step for grinding the Luffa cylindrica which has passed through the Luffa cylindrica washing step a mixing step for mixing the ground Luffa cylindrica which has passed through the grinding step, with purified water a filtering step for filtering the mixture produced through the mixing step a heating step for heating the filtered mixture which has passed through the filtering step and a sterilization packaging step for packaging and sterilizing the mixture which has passed through the heating step.COPYRIGHT KIPO 2014[Reference numerals] (AA) Start (BB) End (S101) Luffa cylindrica washing step (S103) Grinding step (S105) Mixing step (S107) Filtering step (S109) Heating step (S111) Sterilization packaging step본 발명은 영양성분이 증진된 수세미즙의 제조방법에 관한 것으로, 더욱 상세하게는 수세미를 세척하는 수세미세척단계, 전술한 수세미세척단계를 거친 수세미를 분쇄하는 분쇄단계, 전술한 분쇄단계를 거쳐 분쇄된 수세미에 정제수를 혼합하는 혼합단계, 전술한 혼합단계를 거쳐 제조된 혼합물을 여과하는 여과단계, 전술한 여과단계를 거쳐 여과된 혼합물을 가열하는 가열단계 및 전술한 가열단계를 거친 혼합물을 포장하고 멸균처리하는 포장멸균단계로 이루어진다.